J 2012

SUMO Wrestles with Recombination

ALTMANNOVÁ, Veronika, Peter KOLESÁR and Lumír KREJČÍ

Basic information

Original name

SUMO Wrestles with Recombination

Authors

ALTMANNOVÁ, Veronika (203 Czech Republic, belonging to the institution), Peter KOLESÁR (703 Slovakia, belonging to the institution) and Lumír KREJČÍ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Biomolecules, Basel, Switzerland, MDPI AG, 2012, 2218-273X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

RIV identification code

RIV/00216224:14310/12:00057622

Organization unit

Faculty of Science

DOI

UT WoS

000215132700003

Keywords in English

SUMO homologous recombination

Tags

Tags

International impact, Reviewed
Změněno: 11/4/2013 18:22, Ing. Andrea Mikešková

Abstract

V originále

DNA double-strand breaks (DSBs) comprise one of the most toxic DNA lesions, as the failure to repair a single DSB has detrimental consequences on the cell. Homologous recombination (HR) constitutes an error-free repair pathway for the repair of DSBs. On the other hand, when uncontrolled, HR can lead to genome rearrangements and needs to be tightly regulated. In recent years, several proteins involved in different steps of HR have been shown to undergo modification by small ubiquitin-like modifier (SUMO) peptide and it has been suggested that deficient sumoylation impairs the progression of HR. This review addresses specific effects of sumoylation on the properties of various HR proteins and describes its importance for the homeostasis of DNA repetitive sequences. The article further illustrates the role of sumoylation in meiotic recombination and the interplay between SUMO and other post-translational modifications.

Links

EE2.3.09.0186, research and development project
Name: Mendelovo centrum pro vzdělávání v biologii, biomedicíně a bioinformatice
GAP207/12/2323, research and development project
Name: Endonuleazová a translokázová aktivita v restričních-modifikáčních komplexéch typu I
Investor: Czech Science Foundation
GA301/09/1917, research and development project
Name: Štěpení replikačních-rekombinačních DNA meziproduktů a jejich úloha při nestabilitě genomu
Investor: Czech Science Foundation
GD203/09/H046, research and development project
Name: Biochemie na rozcestí mezi in silico a in vitro
Investor: Czech Science Foundation
ME10048, research and development project
Name: Vliv post-translačních modifikací na DNA opravu a rekombinaci.
Investor: Ministry of Education, Youth and Sports of the CR, Research and Development Programme KONTAKT (ME)
MUNI/A/0822/2011, interní kód MU
Name: Molekulární a buněčná biologie v biomedicíně
Investor: Masaryk University, Category A