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@article{1066983,
author = {Kayserova, J. and Sismova, K. and ZentsovaandJaresova, I. and Katina, Stanislav and Vernerova, E. and Polouckova, A. and Capkova, S. and Malinova, V. and Striz, I. and Sediva, A.},
article_location = {Spain},
article_number = {2},
keywords = {Allergic rhinitis. Allergy. Atopic dermatitis. Single nucleotide polymorphism. Cytokines.},
language = {eng},
issn = {1018-9068},
journal = {Journal of Investigational Allergology and Clinical Immunology},
title = {A Prospective Study in Children With a Severe Form of Atopic Dermatitis: Clinical Outcome in Relation to Cytokine Gene Polymorphisms},
url = {http://www.jiaci.org/issues/vol22issue2/vol22issue02-3.htm},
volume = {22},
year = {2012}
}
TY - JOUR
ID - 1066983
AU - Kayserova, J. - Sismova, K. - Zentsova-Jaresova, I. - Katina, Stanislav - Vernerova, E. - Polouckova, A. - Capkova, S. - Malinova, V. - Striz, I. - Sediva, A.
PY - 2012
TI - A Prospective Study in Children With a Severe Form of Atopic Dermatitis: Clinical Outcome in Relation to Cytokine Gene Polymorphisms
JF - Journal of Investigational Allergology and Clinical Immunology
VL - 22
IS - 2
SP - 92-101
EP - 92-101
PB - INTERASMA
SN - 10189068
KW - Allergic rhinitis. Allergy. Atopic dermatitis. Single nucleotide polymorphism. Cytokines.
UR - http://www.jiaci.org/issues/vol22issue2/vol22issue02-3.htm
L2 - http://www.jiaci.org/issues/vol22issue2/vol22issue02-3.htm
N2 - Background and Objective: The course of atopic dermatitis (AD) in childhood is characterized by typical changes in phenotype, including a shift from skin involvement to respiratory allergy usually around the third year of age. We thus designed a prospective study to monitor the outcome of severe AD and to investigate the association between cytokine gene polymorphisms and clinical manifestations. Methods: Clinical and laboratory follow-up of 94 patients with severe AD and 103 healthy controls was performed using routine methodology. Allele, genotype, and haplotype frequencies of single nucleotide polymorphisms of 13 selected cytokine/receptor genes were analyzed using PCR with sequence-specific primers. Results: In our study, genotypes of 7 polymorphisms-IL-4 -1098G/T and -590C/T, IL-6 -174C/G and nt565A/G, and IL-10 -1082A/G, -819C/T, and -592A/C were significantly associated with atopic AD (P<.05). A significant association was also found for TNF-alpha AA and IL-4 GC haplotypes and AD. We confirm the progressive clinical improvement of AD together with a decrease in the severity index SCORAD (SCORing atopic dermatitis) during childhood (P<.05). We found significant differences between IL-4Ralpha +1902 A/G and positivity of tree pollen-specific IgE (P<.05) in the AD group. Moreover, a weak association was also found between IL-10 -819C/T and IL-10 -590A/C and the appearance of allergic rhinitis (P<0.1). Conclusions: We confirmed a clinical shift in allergic phenotype in the first 3 years of life, and showed an association between IL-4, IL-6, and IL-10 polymorphisms and AD. Our data indicate that IL-4alpha and IL-10 polymorphisms may be considered predictive factors of respiratory allergy in children with AD.
ER -
KAYSEROVA, J., K. SISMOVA, I. ZENTSOVA-JARESOVA, Stanislav KATINA, E. VERNEROVA, A. POLOUCKOVA, S. CAPKOVA, V. MALINOVA, I. STRIZ and A. SEDIVA. A Prospective Study in Children With a Severe Form of Atopic Dermatitis: Clinical Outcome in Relation to Cytokine Gene Polymorphisms. \textit{Journal of Investigational Allergology and Clinical Immunology}. Spain: INTERASMA, 2012, vol.~22, No~2, p.~92-101. ISSN~1018-9068.
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