| MOTOVSKA, Z., D. ODVODYOVA, M. KARPISEK, H. HRABAKOVA, V. KOCKA, I. SIMKOVA, Stanislav KATINA and P. WIDIMSKY. Platelet-derived chemokines, PF-4 and RANTES, are significantly increased in hemodynamically significant degenerative aortic stenosis. International Journal of Cardiology. Ireland: Elsevier, 2011, vol. 152, No 2, p. 273-275. ISSN 0167-5273. Available from: https://dx.doi.org/10.1016/j.ijcard.2011.08.021. |
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@article{1066991,
author = {Motovska, Z. and Odvodyova, D. and Karpisek, M. and Hrabakova, H. and Kocka, V. and Simkova, I. and Katina, Stanislav and Widimsky, P.},
article_location = {Ireland},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.ijcard.2011.08.021},
keywords = {Degenerative aortic stenosis; Platelet-derived chemokines; Platelet factor-4 (CXCL4); RANTES (CCL5)},
language = {eng},
issn = {0167-5273},
journal = {International Journal of Cardiology},
title = {Platelet-derived chemokines, PF-4 and RANTES, are significantly increased in hemodynamically significant degenerative aortic stenosis},
url = {http://www.sciencedirect.com/science/article/pii/S0167527311008618},
volume = {152},
year = {2011}
}
TY - JOUR
ID - 1066991
AU - Motovska, Z. - Odvodyova, D. - Karpisek, M. - Hrabakova, H. - Kocka, V. - Simkova, I. - Katina, Stanislav - Widimsky, P.
PY - 2011
TI - Platelet-derived chemokines, PF-4 and RANTES, are significantly increased in hemodynamically significant degenerative aortic stenosis
JF - International Journal of Cardiology
VL - 152
IS - 2
SP - 273-275
EP - 273-275
PB - Elsevier
SN - 01675273
KW - Degenerative aortic stenosis
KW - Platelet-derived chemokines
KW - Platelet factor-4 (CXCL4)
KW - RANTES (CCL5)
UR - http://www.sciencedirect.com/science/article/pii/S0167527311008618
N2 - Aortic valve stenosis (AoS) is the most common acquired valvular disorder found in developed countries, being present in 2% to 7% of adults over the age of 65 [1], [2] and [3]. Calcified AoS is a chronic progressive disease. The pathomechanisms leading to valve degeneration remain unknown. Valve disease shares many features with atherosclerosis. Platelet activation is an important constituent of the atherosclerotic process [4] and [5]. The study focused on two platelet-derived chemokines, which bridge three important components of atherogenesis: platelet activation, inflammation, and generation of atheroma. The study group was comprised of 124 consecutive patients being considered for aortic valve replacement for symptomatic degenerative trileaflet valvular AoS, and were undergoing cardiac catheterization in the Cardiocentre [6]. The exclusion criterion was the presence of an additional hemodynamically significant valve disease.
ER -
MOTOVSKA, Z., D. ODVODYOVA, M. KARPISEK, H. HRABAKOVA, V. KOCKA, I. SIMKOVA, Stanislav KATINA and P. WIDIMSKY. Platelet-derived chemokines, PF-4 and RANTES, are significantly increased in hemodynamically significant degenerative aortic stenosis. \textit{International Journal of Cardiology}. Ireland: Elsevier, 2011, vol.~152, No~2, p.~273-275. ISSN~0167-5273. Available from: https://dx.doi.org/10.1016/j.ijcard.2011.08.021.
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