A significance of additional chromosomal aberrations and other
variables on post transplantation outcome of patients with CML

J 2005

A significance of additional chromosomal aberrations and other variables on post transplantation outcome of patients with CML

VRANOVA, V., Stanislav KATINA, G. KIRSCHNEROVA, M. MISTRIK, J. LAKOTA et. al.

Basic information

Original name

A significance of additional chromosomal aberrations and other variables on post transplantation outcome of patients with CML

Authors

VRANOVA, V. (703 Slovakia, guarantor), Stanislav KATINA (703 Slovakia, belonging to the institution), G. KIRSCHNEROVA (703 Slovakia), M. MISTRIK (703 Slovakia), J. LAKOTA (703 Slovakia), J. HORAKOVA, (703 Slovakia) and A. TOTHOVA (703 Slovakia)

Edition

Neoplasma, Blarislava, Slovakia, Slovak Academy of Sciences, 2005, 0028-2685

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10103 Statistics and probability

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 0.731

RIV identification code

RIV/00216224:14310/05:00061111

Organization unit

Faculty of Science

UT WoS

000232222100005

Keywords in English

chronic myeloic leukemia CML; allogenic stem cell transplantation SCT; additional chromosomal aberations; post transplantation outcome; survival analysis

Abstract

V originále

Chronic myeloic leukemia (CML) is a malignant disease of hematopoietic stem cell characterized by the bcr/abl gene rearrangement. Allogeneic transplantation of stem cells (SCT) is a routinely used treatment method of patients with this diagnosis and remains the only curative mode of treatment. From January 1990 to December 2002, 78 patients with CML underwent allogeneic transplantation and were examined at the Department of Genetics in the National Cancer Institute in Bratislava. Using conventional cytogenetic and FISH 6 patients (7.7%) showed additional chromosomal changes before SCT. These patients had statistically worse post transplantation prognosis compared to the patients without additional changes before SCT (mean survival in month+/-standard error (58.08 (+/-6.70) vs. 5.17 (+/-0.98), p-value=0.001), patient mortality (67% vs. 31%)). In addition five other variables were evaluated for transplant outcome, namely, patient's age at the time of transplantation, sibling or non-sibling donor, higher than 1st chronic phase CML, time from diagnosis to transplantation and sex of donor and recipient. Only the comparison of HLA-identical sibling transplantation to unrelated donor transplantation was statistically significant (mean survival in month- 56.6 (+/-7.2) vs. 13 (+/-0.0), patient mortality 31% vs. 67%).

Links

CZ.1.07/2.2.00/15.0203, interní kód MU

Name: Univerzitní výuka matematiky v měnícím se světě (Acronym: Univerzitní výuka matematiky)

Investor: Ministry of Education, Youth and Sports of the CR, 2.2 Higher education

Citovat

VRANOVA, V., Stanislav KATINA, G. KIRSCHNEROVA, M. MISTRIK, J. LAKOTA, J. HORAKOVA, and A. TOTHOVA. A significance of additional chromosomal aberrations and other variables on post transplantation outcome of patients with CML. Neoplasma. Blarislava, Slovakia: Slovak Academy of Sciences, 2005, vol. 52, No 1, p. 381-387. ISSN 0028-2685.

@article{1067024,
   author = {Vranova, V. and Katina, Stanislav and Kirschnerova, G. and Mistrik, M. and Lakota, J. and Horakova,, J. and Tothova, A.},
   article_location = {Blarislava, Slovakia},
   article_number = {1},
   keywords = {chronic myeloic leukemia CML; allogenic stem cell transplantation SCT; additional chromosomal aberations; post transplantation outcome; survival analysis},
   language = {eng},
   issn = {0028-2685},
   journal = {Neoplasma},
   title = {A significance of additional chromosomal aberrations and other variables on post transplantation outcome of patients with CML},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/16151581},
   volume = {52},
   year = {2005}
}

TY  - JOUR
ID  - 1067024
AU  - Vranova, V. - Katina, Stanislav - Kirschnerova, G. - Mistrik, M. - Lakota, J. - Horakova,, J. - Tothova, A.
PY  - 2005
TI  - A significance of additional chromosomal aberrations and other variables on post transplantation outcome of patients with CML
JF  - Neoplasma
VL  - 52
IS  - 1
SP  - 381-387
EP  - 381-387
PB  - Slovak Academy of Sciences
SN  - 00282685
KW  - chronic myeloic leukemia CML
KW  - allogenic stem cell transplantation SCT
KW  - additional chromosomal aberations
KW  - post transplantation outcome
KW  - survival analysis
UR  - http://www.ncbi.nlm.nih.gov/pubmed/16151581
N2  - Chronic myeloic leukemia (CML) is a malignant disease of hematopoietic stem cell characterized by the bcr/abl gene rearrangement. Allogeneic transplantation of stem cells (SCT) is a routinely used treatment method of patients with this diagnosis and remains the only curative mode of treatment. From January 1990 to December 2002, 78 patients with CML underwent allogeneic transplantation and were examined at the Department of Genetics in the National Cancer Institute in Bratislava. Using conventional cytogenetic and FISH 6 patients (7.7%) showed additional chromosomal changes before SCT. These patients had statistically worse post transplantation prognosis compared to the patients without additional changes before SCT (mean survival in month+/-standard error (58.08 (+/-6.70) vs. 5.17 (+/-0.98), p-value=0.001), patient mortality (67% vs. 31%)). In addition five other variables were evaluated for transplant outcome, namely, patient's age at the time of transplantation, sibling or non-sibling donor, higher than 1st chronic phase CML, time from diagnosis to transplantation and sex of donor and recipient. Only the comparison of HLA-identical sibling transplantation to unrelated donor transplantation was statistically significant (mean survival in month- 56.6 (+/-7.2) vs. 13 (+/-0.0), patient mortality 31% vs. 67%).
ER  -

VRANOVA, V., Stanislav KATINA, G. KIRSCHNEROVA, M. MISTRIK, J. LAKOTA, J. HORAKOVA, and A. TOTHOVA. A significance of additional chromosomal aberrations and other variables on post transplantation outcome of patients with CML. \textit{Neoplasma}. Blarislava, Slovakia: Slovak Academy of Sciences, 2005, vol.~52, No~1, p.~381-387. ISSN~0028-2685.

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