MAKATSORI, A., R. DUNCKO, F. MONCEK, I. LODER, Stanislav KATINA a D. JEZOVA. Modulation of neuroendocrine response and non-verbal behavior during psychosocial stress in healthy volunteers by the glutamate release-inhibiting drug lamotrigine. Neuroendocrinology, Karger AG, Basel, 2004, roč. 79, č. 1, s. 34-42. ISSN 1423-0194. doi:10.1159/000076045.
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Základní údaje
Originální název Modulation of neuroendocrine response and non-verbal behavior during psychosocial stress in healthy volunteers by the glutamate release-inhibiting drug lamotrigine
Autoři MAKATSORI, A. (703 Slovensko), R. DUNCKO (703 Slovensko), F. MONCEK (703 Slovensko), I. LODER (703 Slovensko), Stanislav KATINA (703 Slovensko, domácí) a D. JEZOVA (703 Slovensko, garant).
Vydání Neuroendocrinology, Karger AG, Basel, 2004, 1423-0194.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor Statistics and probability
Stát vydavatele Švýcarsko
Utajení není předmětem státního či obchodního tajemství
WWW URL
Kód RIV RIV/00216224:14310/04:00061112
Organizační jednotka Přírodovědecká fakulta
Doi http://dx.doi.org/10.1159/000076045
UT WoS 000188600200004
Klíčová slova anglicky Lamotrigine; Glutamate; Non-verbal behavior; Stress; Catecholamines; Adrenal steroids; Growth hormone
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnil: doc. PaedDr. RNDr. Stanislav Katina, Ph.D., učo 111465. Změněno: 21. 2. 2013 16:04.
Anotace
The present work was aimed at verifying the following hypotheses: (a) lamotrigine, a drug used to treat mood disorders, affects regulation of stress hormone release in humans, and (b) non-verbal behavior during mental stress situations (public speech) is related to hormonal responses. To achieve these aims, we performed a controlled, double-blind study investigating hormonal responses and non-verbal behavior during public speech in healthy subjects with placebo or lamotrigine (300 mg per os) pretreatment. The stress procedure was performed in 19 young healthy males 5 h following drug or placebo administration. Data were obtained from cardiovascular monitoring, blood and saliva samples, as well as the video-recorded speech. Pre-stress hormone levels were not affected by lamotrigine treatment. Lamotrigine significantly inhibited diastolic blood pressure, growth hormone and cortisol increases during psychosocial stress. In contrast, it potentiated plasma renin activity and aldosterone responses. Non-verbal behavior analysis revealed a correlation between catecholamines and submissive or flight behavior in controls, while between catecholamines and displacement behavior following lamotrigine administration. In conclusion, effects of lamotrigine on hormone release might be of value for its mood-stabilizing action used in the treatment of bipolar disorder. The data are in support of a stimulatory role of glutamate in the control of cortisol and growth hormone release during psychosocial stress in humans; however, further studies using more selective drugs are needed to prove this suggestion. The effects on plasma renin activity and aldosterone release observed seem to be related to other actions of lamotrigine.
Návaznosti
CZ.1.07/2.2.00/15.0203, interní kód MUNázev: Univerzitní výuka matematiky v měnícím se světě (Akronym: Univerzitní výuka matematiky)
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Operační program Vzdělávání pro konkurenceschopnost (VK), 2.2 Vysokoškolské vzdělávání
VytisknoutZobrazeno: 21. 9. 2019 03:02