| PĚTROŠOVÁ, Helena, Marie ZOBANÍKOVÁ, Darina ČEJKOVÁ, Lenka MIKALOVÁ, Petra POSPÍŠILOVÁ, Michal STROUHAL, Lei CHEN, Xiang QIN, Donna M. MUZNY, George M. WEINSTOCK a David ŠMAJS. Whole Genome Sequence of Treponema pallidum ssp. pallidum, Strain Mexico A, Suggests Recombination between Yaws and Syphilis Strains. PLOS Neglected Tropical Diseases. 2012, roč. 6, č. 9, s. "nestrankovano", 10 s. ISSN 1935-2735. Dostupné z: https://dx.doi.org/10.1371/journal.pntd.0001832. |
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@article{1069116,
author = {Pětrošová, Helena and Zobaníková, Marie and Čejková, Darina and Mikalová, Lenka and Pospíšilová, Petra and Strouhal, Michal and Chen, Lei and Qin, Xiang and Muzny, Donna M. and Weinstock, George M. and Šmajs, David},
article_number = {9},
doi = {http://dx.doi.org/10.1371/journal.pntd.0001832},
keywords = {Treponema pallidum; Mexico A strain; genome; syphilis; inter-strain recombination},
language = {eng},
issn = {1935-2735},
journal = {PLOS Neglected Tropical Diseases},
note = {Art. No. e1832},
title = {Whole Genome Sequence of Treponema pallidum ssp. pallidum, Strain Mexico A, Suggests Recombination between Yaws and Syphilis Strains},
url = {http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001832},
volume = {6},
year = {2012}
}
TY - JOUR
ID - 1069116
AU - Pětrošová, Helena - Zobaníková, Marie - Čejková, Darina - Mikalová, Lenka - Pospíšilová, Petra - Strouhal, Michal - Chen, Lei - Qin, Xiang - Muzny, Donna M. - Weinstock, George M. - Šmajs, David
PY - 2012
TI - Whole Genome Sequence of Treponema pallidum ssp. pallidum, Strain Mexico A, Suggests Recombination between Yaws and Syphilis Strains
JF - PLOS Neglected Tropical Diseases
VL - 6
IS - 9
SP - "nestrankovano"
EP - "nestrankovano"
SN - 19352735
N1 - Art. No. e1832
KW - Treponema pallidum
KW - Mexico A strain
KW - genome
KW - syphilis
KW - inter-strain recombination
UR - http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001832
L2 - http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001832
N2 - Treponema pallidum is a Gram-negative spirochete that causes diseases with distinct clinical manifestations and uses different transmission strategies. While syphilis (caused by subspecies pallidum) is a worldwide venereal and congenital disease, yaws (caused by subspecies pertenue) is a tropical disease transmitted by direct skin contact. Currently the genetic basis and evolution of these diseases remain unknown. In this study, we describe a high quality whole genome sequence of T. pallidum ssp. pallidum strain Mexico A, determined using the ?next generation? sequencing technique (Illumina). Although the genome of this strain contains no large rearrangements in comparison with other treponemal genomes, we found two genes which combined sequences from both subspecies pallidum and pertenue. The observed mosaic character of these two genes is likely a result of inter-strain recombination between pallidum and pertenue during simultaneous infection of a single host.
ER -
PĚTROŠOVÁ, Helena, Marie ZOBANÍKOVÁ, Darina ČEJKOVÁ, Lenka MIKALOVÁ, Petra POSPÍŠILOVÁ, Michal STROUHAL, Lei CHEN, Xiang QIN, Donna M. MUZNY, George M. WEINSTOCK a David ŠMAJS. Whole Genome Sequence of Treponema pallidum ssp. pallidum, Strain Mexico A, Suggests Recombination between Yaws and Syphilis Strains. \textit{PLOS Neglected Tropical Diseases}. 2012, roč.~6, č.~9, s.~''nestrankovano'', 10 s. ISSN~1935-2735. Dostupné z: https://dx.doi.org/10.1371/journal.pntd.0001832.
|
