Complete genome sequence of Treponema pallidum strain DAL-1

ZOBANÍKOVÁ, Marie, Pavol MIKOLKA, Darina ČEJKOVÁ, Petra POSPÍŠILOVÁ, Lei CHEN, Michal STROUHAL, Xiang QIN, George M. WEINSTOCK and David ŠMAJS. Complete genome sequence of Treponema pallidum strain DAL-1. Standards in Genomic Sciences. 2012, vol. 7, No 1, p. "nestrankovano", 13 pp. ISSN 1944-3277. Available from: https://dx.doi.org/10.4056/sigs.2615838.

Basic information

• Original name: Complete genome sequence of Treponema pallidum strain DAL-1
• Authors: ZOBANÍKOVÁ, Marie (203 Czech Republic, guarantor, belonging to the institution), Pavol MIKOLKA (703 Slovakia, belonging to the institution), Darina ČEJKOVÁ (203 Czech Republic, belonging to the institution), Petra POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution), Lei CHEN (840 United States of America), Michal STROUHAL (203 Czech Republic, belonging to the institution), Xiang QIN (840 United States of America), George M. WEINSTOCK (840 United States of America) and David ŠMAJS (203 Czech Republic, belonging to the institution).
• Edition: Standards in Genomic Sciences, 2012, 1944-3277.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: Genetics and molecular biology
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 2.007
• RIV identification code: RIV/00216224:14110/12:00057665
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.4056/sigs.2615838
• UT WoS: 000314405900002
• Keywords in English: Spirochaetaceae; Treponema pallidum; syphilis
• Tags: International impact

Abstract

Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing methods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain.

Links

• GA310/07/0321, research and development project: Name: Komparativní genomové sekvencování patogenních treponem a transkriptomová analýza T. pallidum ssp. pallidum

Investor: Czech Science Foundation

• MSM0021622415, plan (intention): Name: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations