| VAŠKŮ, Anna, Julie BIENERTOVÁ VAŠKŮ, Jiří PAŘENICA, Monika PÁVKOVÁ GOLDBERGOVÁ, Jolana LIPKOVÁ, Filip ZLÁMAL, Petr KALA a Jindřich ŠPINAR. ACE2 gene polymorphisms and invasively measured central pulse pressure in cardiac patients indicated for coronarography. Journal of the Renin-Angiotensin-Aldosterone System. Holandsko: SAGE, 2013, roč. 14, č. 3, s. 220-226. ISSN 1470-3203. doi:10.1177/1470320312460291. |
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@article{1069210,
author = {Vašků, Anna and Bienertová Vašků, Julie and Pařenica, Jiří and Pávková Goldbergová, Monika and Lipková, Jolana and Zlámal, Filip and Kala, Petr and Špinar, Jindřich},
article_location = {Holandsko},
article_number = {3},
doi = {http://dx.doi.org/10.1177/1470320312460291},
keywords = {ACE2; polymorphism; pulse pressure; severity},
language = {eng},
issn = {1470-3203},
journal = {Journal of the Renin-Angiotensin-Aldosterone System},
title = {ACE2 gene polymorphisms and invasively measured central pulse pressure in cardiac patients indicated for coronarography},
url = {http://jra.sagepub.com/content/early/2012/10/17/1470320312460291.full.pdf+html},
volume = {14},
year = {2013}
}
TY - JOUR
ID - 1069210
AU - Vašků, Anna - Bienertová Vašků, Julie - Pařenica, Jiří - Pávková Goldbergová, Monika - Lipková, Jolana - Zlámal, Filip - Kala, Petr - Špinar, Jindřich
PY - 2013
TI - ACE2 gene polymorphisms and invasively measured central pulse pressure in cardiac patients indicated for coronarography
JF - Journal of the Renin-Angiotensin-Aldosterone System
VL - 14
IS - 3
SP - 220-226
EP - 220-226
PB - SAGE
SN - 14703203
KW - ACE2
KW - polymorphism
KW - pulse pressure
KW - severity
UR - http://jra.sagepub.com/content/early/2012/10/17/1470320312460291.full.pdf+html
N2 - The objective of this research was to determine whether invasively measured central pulse pressure (PP) in patients indicated for coronarography is associated with two common polymorphisms in the ACE2 region (rs4646156 and rs4646174). Methods: A total of 307 patients were enrolled in the study. The genotyping of both SNPs from peripheral blood samples was carried out using 5-exonuclease (Taqman) chemistry on the ABI Prism 7000 system (Applied Biosystems, Foster City, CA, USA). Results: In both polymorphisms, the associations with central PP were found to be highly significant when all five possible genotypes in the population had been compared (p = 0.0001). In men, there was a higher incidence of previous myocardial infarction in G0 genotype carriers of rs54646174 (OR ratio = 7; p = 0.005). The AA genotype of rs4646156 had a 7.81 higher risk of severe angina pectoris in women (OR = 7.81, p = 0.05). A significant difference in allelic frequency of ACE2rs4646174 was found between women with and without significant stenoses of the circumflex branch of the left coronary artery. Conclusion: More research into the role of ACE2 genetic variability in PP regulations is necessary for more detailed physiological and pathophysiological comprehension of PP regulation.
ER -
VAŠKŮ, Anna, Julie BIENERTOVÁ VAŠKŮ, Jiří PAŘENICA, Monika PÁVKOVÁ GOLDBERGOVÁ, Jolana LIPKOVÁ, Filip ZLÁMAL, Petr KALA a Jindřich ŠPINAR. ACE2 gene polymorphisms and invasively measured central pulse pressure in cardiac patients indicated for coronarography. \textit{Journal of the Renin-Angiotensin-Aldosterone System}. Holandsko: SAGE, 2013, roč.~14, č.~3, s.~220-226. ISSN~1470-3203. doi:10.1177/1470320312460291.
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