VAŠKŮ, Anna, Julie BIENERTOVÁ VAŠKŮ, Jiří PAŘENICA, Monika PÁVKOVÁ GOLDBERGOVÁ, Jolana LIPKOVÁ, Filip ZLÁMAL, Petr KALA and Jindřich ŠPINAR. ACE2 gene polymorphisms and invasively measured central pulse pressure in cardiac patients indicated for coronarography. Journal of the Renin-Angiotensin-Aldosterone System. Holandsko: SAGE, 2013, vol. 14, No 3, p. 220-226. ISSN 1470-3203. doi:10.1177/1470320312460291.
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Basic information
Original name ACE2 gene polymorphisms and invasively measured central pulse pressure in cardiac patients indicated for coronarography
Name in Czech Polymorfismus v genu pro ACE2 a invazivně meřený centrální pulzní tlak u kardiaků indikovaných ke koronarografii
Authors VAŠKŮ, Anna (203 Czech Republic, guarantor, belonging to the institution), Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution), Jiří PAŘENICA (203 Czech Republic, belonging to the institution), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic, belonging to the institution), Jolana LIPKOVÁ (203 Czech Republic, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Petr KALA (203 Czech Republic, belonging to the institution) and Jindřich ŠPINAR (203 Czech Republic, belonging to the institution).
Edition Journal of the Renin-Angiotensin-Aldosterone System, Holandsko, SAGE, 2013, 1470-3203.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.271
RIV identification code RIV/00216224:14110/13:00065567
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1177/1470320312460291
UT WoS 000323207100005
Keywords (in Czech) ACE2; polymorfismus; pulsní tlak; závažnost
Keywords in English ACE2; polymorphism; pulse pressure; severity
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 11. 10. 2013 14:40.
Abstract
The objective of this research was to determine whether invasively measured central pulse pressure (PP) in patients indicated for coronarography is associated with two common polymorphisms in the ACE2 region (rs4646156 and rs4646174). Methods: A total of 307 patients were enrolled in the study. The genotyping of both SNPs from peripheral blood samples was carried out using 5-exonuclease (Taqman) chemistry on the ABI Prism 7000 system (Applied Biosystems, Foster City, CA, USA). Results: In both polymorphisms, the associations with central PP were found to be highly significant when all five possible genotypes in the population had been compared (p = 0.0001). In men, there was a higher incidence of previous myocardial infarction in G0 genotype carriers of rs54646174 (OR ratio = 7; p = 0.005). The AA genotype of rs4646156 had a 7.81 higher risk of severe angina pectoris in women (OR = 7.81, p = 0.05). A significant difference in allelic frequency of ACE2rs4646174 was found between women with and without significant stenoses of the circumflex branch of the left coronary artery. Conclusion: More research into the role of ACE2 genetic variability in PP regulations is necessary for more detailed physiological and pathophysiological comprehension of PP regulation.
Links
NS10206, research and development projectName: Asociace polymorfismů v genech pro metaloproteinázy, jejich inhibitory, ACE a ACE2 s centrálním pulsním tlakem u kardiovaskulárních pacientů
Investor: Ministry of Health of the CR
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