PÁVKOVÁ GOLDBERGOVÁ, Monika, Nikolas PÁVEK, Jolana LIPKOVÁ, Jiří JARKOVSKÝ, Martina STOURACOVA, Jindra GATTEROVA, Anna VAŠKŮ, Miroslav SOUČEK and Petr NĚMEC. Circulating cytokine pattern and factors describing rheumatoid arthritis: IL-15 as one of the biomarkers for RA? Biomarkers. Spojené státy americké: INFORMA HEALTHCARE, 2012, vol. 17, No 7, p. 655-667. ISSN 1354-750X. doi:10.3109/1354750X.2012.719036.
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Basic information
Original name Circulating cytokine pattern and factors describing rheumatoid arthritis: IL-15 as one of the biomarkers for RA?
Name in Czech Cirkulující cytokiny a faktory popisující rheumatoidní artritidu: IL 15 jako jeden z biomarkerů pro RA?
Authors PÁVKOVÁ GOLDBERGOVÁ, Monika (203 Czech Republic, guarantor, belonging to the institution), Nikolas PÁVEK (203 Czech Republic, belonging to the institution), Jolana LIPKOVÁ (203 Czech Republic, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Martina STOURACOVA (203 Czech Republic), Jindra GATTEROVA (203 Czech Republic), Anna VAŠKŮ (203 Czech Republic, belonging to the institution), Miroslav SOUČEK (203 Czech Republic, belonging to the institution) and Petr NĚMEC (203 Czech Republic, belonging to the institution).
Edition Biomarkers, Spojené státy americké, INFORMA HEALTHCARE, 2012, 1354-750X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.879
RIV identification code RIV/00216224:14110/12:00061363
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.3109/1354750X.2012.719036
UT WoS 000310077200011
Keywords (in Czech) rheumatoidní artritida; interleukin; cirkulující hladina
Keywords in English rheumatoid arthritis; cytokine; interleukin; circulating level
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 1/3/2013 14:18.
Abstract
The aim of study was to examine relationship among levels of cytokines (IL-6, IL-13, IL-15, TNF-alpha) and chemokine (IL-8), production of autoantibodies, radiographic progression, and factors describing rheumatoid arthritis (RA). A total of 156 RA patients according to ACR criteria, and 55 control subjects were recruited into study. We observed higher levels of IL-15 within RA patients compared to healthy controls. Correlations among cytokine levels and the measures of rheumatoid factors, anti-CCP, measures of disease activity, and radiographic progression were observed. We conclude that IL-15 level in circulation could serve as one of the biomarkers for RA detection.
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