BAREŠ, Martin, Ivica HUSÁROVÁ and Ovidiu V. LUNGU. Essential Tremor, the Cerebellum, and Motor Timing: Towards Integrating Them into One Complex Entity. Tremor and Other Hyperkinetic Movements. New York: Center for Digital Research and Scholars, 2012, vol. 2012, No 2, p. "nestránkováno", 9 pp. ISSN 2160-8288.
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Basic information
Original name Essential Tremor, the Cerebellum, and Motor Timing: Towards Integrating Them into One Complex Entity
Authors BAREŠ, Martin (203 Czech Republic, guarantor, belonging to the institution), Ivica HUSÁROVÁ (703 Slovakia, belonging to the institution) and Ovidiu V. LUNGU (840 United States of America).
Edition Tremor and Other Hyperkinetic Movements, New York, Center for Digital Research and Scholars, 2012, 2160-8288.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
RIV identification code RIV/00216224:14740/12:00061422
Organization unit Central European Institute of Technology
Keywords in English Cerebellum; essential tremor; motor timing; prediction; neurodegeneration
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 6. 4. 2013 20:40.
Abstract
Essential tremor (ET) is the most common movement disorder in humans. It is characterized by a postural and kinetic tremor most commonly affecting the forearms and hands. Isolated head tremor has been found in 1–10% of patients, suggesting that ET may be a composite of several phenotypes. The exact pathophysiology of ET is still unknown. ET has been repeatedly shown as a disorder of mild cerebellar degeneration, particularly in postmortem studies. Clinical observations, electrophysiological, volumetric and functional imaging studies all reinforce the fact that the cerebellum is involved in the generation of ET. However, crucial debate exists as to whether ET is a neurodegenerative disease. Data suggesting that it is neurodegenerative include postmortem findings of pathological abnormalities in the brainstem and cerebellum, white matter changes on diffusion tensor imaging, and clinical studies demonstrating an association with cognitive and gait changes. There is also conflicting evidence against ET as a neurodegenerative disease: the improvement of gait abnormalities with ethanol administration, lack of gray matter volume loss on voxel-based morphometry, failure to confirm the prominent presence of Lewy bodies in the locus ceruleus, and other pathological findings. To clarify this issue, future research is needed to describe the mechanism of cellular changes in the ET brain and to understand the order in which they occur. The cerebellum has been shown to be involved in the timing of movement and sensation, acting as an internal timing system that provides the temporal representation of salient events spanning hundreds of milliseconds. It has been reported that cerebellar timing function is altered in patients with ET, showing an increased variability of rhythmic hand movements as well as diminished performance during predictive motor timing task. Based on current knowledge and observations, we argue that ET is essentially linked with cerebellar degeneration, or at least cerebellar dysfunction, together with disturbance of motor timing. We explain the context of our current understanding on this topic, highlighting possible clinical consequences for patients suffering from ET and future research directions.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
MSM0021622404, plan (intention)Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
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