BAREŠ, Martin, Ivica HUSÁROVÁ a Ovidiu V. LUNGU. Essential Tremor, the Cerebellum, and Motor Timing: Towards Integrating Them into One Complex Entity. Tremor and Other Hyperkinetic Movements. New York: Center for Digital Research and Scholars, 2012, roč. 2012, č. 2, s. "nestránkováno", 9 s. ISSN 2160-8288.
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Základní údaje
Originální název Essential Tremor, the Cerebellum, and Motor Timing: Towards Integrating Them into One Complex Entity
Autoři BAREŠ, Martin (203 Česká republika, garant, domácí), Ivica HUSÁROVÁ (703 Slovensko, domácí) a Ovidiu V. LUNGU (840 Spojené státy).
Vydání Tremor and Other Hyperkinetic Movements, New York, Center for Digital Research and Scholars, 2012, 2160-8288.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30000 3. Medical and Health Sciences
Stát vydavatele Spojené státy
Utajení není předmětem státního či obchodního tajemství
Kód RIV RIV/00216224:14740/12:00061422
Organizační jednotka Středoevropský technologický institut
Klíčová slova anglicky Cerebellum; essential tremor; motor timing; prediction; neurodegeneration
Štítky ok, rivok
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Olga Křížová, učo 56639. Změněno: 6. 4. 2013 20:40.
Essential tremor (ET) is the most common movement disorder in humans. It is characterized by a postural and kinetic tremor most commonly affecting the forearms and hands. Isolated head tremor has been found in 1–10% of patients, suggesting that ET may be a composite of several phenotypes. The exact pathophysiology of ET is still unknown. ET has been repeatedly shown as a disorder of mild cerebellar degeneration, particularly in postmortem studies. Clinical observations, electrophysiological, volumetric and functional imaging studies all reinforce the fact that the cerebellum is involved in the generation of ET. However, crucial debate exists as to whether ET is a neurodegenerative disease. Data suggesting that it is neurodegenerative include postmortem findings of pathological abnormalities in the brainstem and cerebellum, white matter changes on diffusion tensor imaging, and clinical studies demonstrating an association with cognitive and gait changes. There is also conflicting evidence against ET as a neurodegenerative disease: the improvement of gait abnormalities with ethanol administration, lack of gray matter volume loss on voxel-based morphometry, failure to confirm the prominent presence of Lewy bodies in the locus ceruleus, and other pathological findings. To clarify this issue, future research is needed to describe the mechanism of cellular changes in the ET brain and to understand the order in which they occur. The cerebellum has been shown to be involved in the timing of movement and sensation, acting as an internal timing system that provides the temporal representation of salient events spanning hundreds of milliseconds. It has been reported that cerebellar timing function is altered in patients with ET, showing an increased variability of rhythmic hand movements as well as diminished performance during predictive motor timing task. Based on current knowledge and observations, we argue that ET is essentially linked with cerebellar degeneration, or at least cerebellar dysfunction, together with disturbance of motor timing. We explain the context of our current understanding on this topic, highlighting possible clinical consequences for patients suffering from ET and future research directions.
ED1.1.00/02.0068, projekt VaVNázev: CEITEC - central european institute of technology
MSM0021622404, záměrNázev: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
VytisknoutZobrazeno: 2. 10. 2022 11:38