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@proceedings{1070195,
author = {Hlavna, Marián and Stračina, Tibor and Sochor, Jiří and Zítka, Ondřej and Gumulec, Jaromír and Sztalmachová, Markéta and Babula, Petr and Adam, Vojtěch and Kizek, René and Nováková, Marie and Masařík, Michal},
booktitle = {12th Workshop of Physical Chemists and Electrochemists},
keywords = {Haloperidol; superoxide dismutase; glutathione reductase; GSH:GSSG ratio; oxidative stress; FRAP method; guinea pig},
language = {eng},
isbn = {978-80-7375-618-5},
title = {DETERMINATION OF OXIDATIVE STRESS IN GUINEA PIG TREATED BY HALOPERIDOL},
year = {2012}
}
TY - CONF
ID - 1070195
AU - Hlavna, Marián - Stračina, Tibor - Sochor, Jiří - Zítka, Ondřej - Gumulec, Jaromír - Sztalmachová, Markéta - Babula, Petr - Adam, Vojtěch - Kizek, René - Nováková, Marie - Masařík, Michal
PY - 2012
TI - DETERMINATION OF OXIDATIVE STRESS IN GUINEA PIG TREATED BY HALOPERIDOL
SN - 9788073756185
KW - Haloperidol
KW - superoxide dismutase
KW - glutathione reductase
KW - GSH:GSSG ratio
KW - oxidative stress
KW - FRAP method
KW - guinea pig
N2 - Haloperidol is an older antipsychotic used in the treatment of schizophrenia and in the treatment of acute psychotic states and delirium. Due to its strong central antidopaminergic action, it is classified as a highly potent neuroleptic. However, the usage of typical neuroleptic drugs has been limited by the side effects and toxicity produced by them. Therefore is essential to know all possible risks which bring together treatment with these drugs. We decided to measure and compare level of oxidative stress from plasma and erythrocytes from 17 guinea pigs (10 treated and 7 untreated). We were concerned on superoxide dismutase detection,FRAP method, glutathione reductase and reduced and oxidized glutathione GSH:GSSG ratio measurement as a relevant oxidative stress pointer.We treated 17 guinea pigs by haloperidol and measured oxidative stress from plasma and isolated erythrocytes. Haloperidol was present in plasma of treated animals while was undetectable in animals without treatment. In animals treated by haloperidol was significantly increased superoxide dismutase (SOD) and glutathione reductase, which is clear evidence about ROS and oxidative stress. SOD was increased also in isolated erythrocytes and also ratio between reduced and oxidized glutathione(GSH:GSSG) was shifted to oxidative stress state. The present study demonstrates that administration of haloperidol causes significant oxidative stress.
ER -
HLAVNA, Marián, Tibor STRAČINA, Jiří SOCHOR, Ondřej ZÍTKA, Jaromír GUMULEC, Markéta SZTALMACHOVÁ, Petr BABULA, Vojtěch ADAM, René KIZEK, Marie NOVÁKOVÁ and Michal MASAŘÍK. DETERMINATION OF OXIDATIVE STRESS IN GUINEA PIG TREATED BY HALOPERIDOL. In \textit{12th Workshop of Physical Chemists and Electrochemists}. 2012. ISBN~978-80-7375-618-5.
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