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@proceedings{1070200, author = {Cernei, Natalia Vladimirovna and Kominíková, Markéta and Zítka, Ondřej and Gumulec, Jaromír and Masařík, Michal and Adam, Vojtěch and Hubálek, Jaromír and Trnková, Libuše and Stiborová, Marie and Eckschlager, Tomáš and Kizek, René}, booktitle = {12th Workshop of Physical Chemists and Electrochemists}, keywords = {Sarcosine; Hydrophilic interaction chromatography (HILIC); prostate cancer}, language = {eng}, isbn = {978-80-7375-618-5}, title = {HILIC SEPARATION OF SARCOSINE HYPHENATED TO COULOMETRIC DETECTION}, year = {2012} }
TY - CONF ID - 1070200 AU - Cernei, Natalia Vladimirovna - Kominíková, Markéta - Zítka, Ondřej - Gumulec, Jaromír - Masařík, Michal - Adam, Vojtěch - Hubálek, Jaromír - Trnková, Libuše - Stiborová, Marie - Eckschlager, Tomáš - Kizek, René PY - 2012 TI - HILIC SEPARATION OF SARCOSINE HYPHENATED TO COULOMETRIC DETECTION SN - 9788073756185 KW - Sarcosine KW - Hydrophilic interaction chromatography (HILIC) KW - prostate cancer N2 - Recently, sarcosine has been identified as a potential prostate cancer marker. To provide early determination of this compound, number of methods is still developed. Sarcosine is relatively small molecule, which is polar enough to enable separation by chromatography with reverse phase. For this reason we optimized method for separation by Hydrophilic interaction chromatography (HILIC). The aim of this work was to suggest the method for HILIC separation and determination of sarcosine with electrochemical detection. This aim was reached as shown by the limit of detection (350 nM), which was determined from calibration curve. This method is suitable for determination of sarcosine in real samples such as urine. ER -
CERNEI, Natalia Vladimirovna, Markéta KOMINÍKOVÁ, Ondřej ZÍTKA, Jaromír GUMULEC, Michal MASAŘÍK, Vojtěch ADAM, Jaromír HUBÁLEK, Libuše TRNKOVÁ, Marie STIBOROVÁ, Tomáš ECKSCHLAGER and René KIZEK. HILIC SEPARATION OF SARCOSINE HYPHENATED TO COULOMETRIC DETECTION. In \textit{12th Workshop of Physical Chemists and Electrochemists}. 2012. ISBN~978-80-7375-618-5.
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