| OMIDVAR, Nader, Mei Lin MAUNAKEA, Letetia JONES, Sabina ŠEVČÍKOVÁ, Bin YIN, Karen L. HIMMEL, Thelma R. TENNANT, Michelle M. LE BEAU, David A. LARGAESPADA a Scott C. KOGAN. PML-RAR alpha co-operates with Sox4 in acute myeloid leukemia development in mice. Haematologica-The Hematology Journal. PAVIA, ITALY: Ferrata Storti Foundation, 2013, roč. 98, č. 3, s. 424-427. ISSN 0390-6078. doi:10.3324/haematol.2011.057067. |
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@article{1074126,
author = {Omidvar, Nader and Maunakea, Mei Lin and Jones, Letetia and Ševčíková, Sabina and Yin, Bin and Himmel, Karen L. and Tennant, Thelma R. and Le Beau, Michelle M. and Largaespada, David A. and Kogan, Scott C.},
article_location = {PAVIA, ITALY},
article_number = {3},
doi = {http://dx.doi.org/10.3324/haematol.2011.057067},
keywords = {Acute promyelocytic leukemia; PML-RAR alpha; SOX4; mice},
language = {eng},
issn = {0390-6078},
journal = {Haematologica-The Hematology Journal},
title = {PML-RAR alpha co-operates with Sox4 in acute myeloid leukemia development in mice},
url = {http://www.haematologica.org/content/98/3/424.full.pdf+html},
volume = {98},
year = {2013}
}
TY - JOUR
ID - 1074126
AU - Omidvar, Nader - Maunakea, Mei Lin - Jones, Letetia - Ševčíková, Sabina - Yin, Bin - Himmel, Karen L. - Tennant, Thelma R. - Le Beau, Michelle M. - Largaespada, David A. - Kogan, Scott C.
PY - 2013
TI - PML-RAR alpha co-operates with Sox4 in acute myeloid leukemia development in mice
JF - Haematologica-The Hematology Journal
VL - 98
IS - 3
SP - 424-427
EP - 424-427
PB - Ferrata Storti Foundation
SN - 03906078
KW - Acute promyelocytic leukemia
KW - PML-RAR alpha
KW - SOX4
KW - mice
UR - http://www.haematologica.org/content/98/3/424.full.pdf+html
N2 - Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha gene. To identify cooperating pathways to leukemogenesis we crossed MRP8-PML/RARA transgenic mice with BXH-2 mice, which harbor an endogenous murine leukemia virus that causes acute myeloid leukemia. Approximately half of leukemias that arose in this cross showed features of acute promyelocytic leukemia. We identified 22 proviral insertions sites in acute promyelocytic-like leukemias and focused our analysis on insertion at Sox4, a HMG box transcription factor. Using a transplant model, cooperation between PML-RARalpha and Sox4 was confirmed with increased penetrance and reduced latency of disease. Interestingly, karyotypic analysis revealed cytogenetic changes suggesting that the factors combined to initiate but not complete leukemic transformation. The cooperation between these transcription factors is consistent with the paradigm of multiple routes to the disease and reinforces the concept that transcription factor networks are important therapeutic targets in myeloid leukemias.
ER -
OMIDVAR, Nader, Mei Lin MAUNAKEA, Letetia JONES, Sabina ŠEVČÍKOVÁ, Bin YIN, Karen L. HIMMEL, Thelma R. TENNANT, Michelle M. LE BEAU, David A. LARGAESPADA a Scott C. KOGAN. PML-RAR alpha co-operates with Sox4 in acute myeloid leukemia development in mice. \textit{Haematologica-The Hematology Journal}. PAVIA, ITALY: Ferrata Storti Foundation, 2013, roč.~98, č.~3, s.~424-427. ISSN~0390-6078. doi:10.3324/haematol.2011.057067.
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