Informační systém MU
OMIDVAR, Nader, Mei Lin MAUNAKEA, Letetia JONES, Sabina ŠEVČÍKOVÁ, Bin YIN, Karen L. HIMMEL, Thelma R. TENNANT, Michelle M. LE BEAU, David A. LARGAESPADA and Scott C. KOGAN. PML-RAR alpha co-operates with Sox4 in acute myeloid leukemia development in mice. Haematologica-The Hematology Journal. PAVIA, ITALY: Ferrata Storti Foundation, 2013, vol. 98, No 3, p. 424-427. ISSN 0390-6078. doi:10.3324/haematol.2011.057067.
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Basic information
Original name PML-RAR alpha co-operates with Sox4 in acute myeloid leukemia development in mice
Authors OMIDVAR, Nader (840 United States of America, guarantor), Mei Lin MAUNAKEA (840 United States of America), Letetia JONES (840 United States of America), Sabina ŠEVČÍKOVÁ (203 Czech Republic, belonging to the institution), Bin YIN (840 United States of America), Karen L. HIMMEL (840 United States of America), Thelma R. TENNANT (840 United States of America), Michelle M. LE BEAU (840 United States of America), David A. LARGAESPADA (840 United States of America) and Scott C. KOGAN (840 United States of America).
Edition Haematologica-The Hematology Journal, PAVIA, ITALY, Ferrata Storti Foundation, 2013, 0390-6078.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher Italy
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 5.868
RIV identification code RIV/00216224:14110/13:00067529
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.3324/haematol.2011.057067
UT WoS 000317530600019
Keywords in English Acute promyelocytic leukemia; PML-RAR alpha; SOX4; mice
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 6. 8. 2013 17:29.
Abstract
Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha gene. To identify cooperating pathways to leukemogenesis we crossed MRP8-PML/RARA transgenic mice with BXH-2 mice, which harbor an endogenous murine leukemia virus that causes acute myeloid leukemia. Approximately half of leukemias that arose in this cross showed features of acute promyelocytic leukemia. We identified 22 proviral insertions sites in acute promyelocytic-like leukemias and focused our analysis on insertion at Sox4, a HMG box transcription factor. Using a transplant model, cooperation between PML-RARalpha and Sox4 was confirmed with increased penetrance and reduced latency of disease. Interestingly, karyotypic analysis revealed cytogenetic changes suggesting that the factors combined to initiate but not complete leukemic transformation. The cooperation between these transcription factors is consistent with the paradigm of multiple routes to the disease and reinforces the concept that transcription factor networks are important therapeutic targets in myeloid leukemias.
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