LOCHMANOVÁ, Gabriela, Lenka JEDLIČKOVÁ, David POTĚŠIL, Alexandra TOMANCOVÁ, Jan VERNER, Šárka POSPÍŠILOVÁ, Michael DOUBEK, Jiří MAYER and Zbyněk ZDRÁHAL. Potential biomarkers for early detection of acute graft-versus-host disease. Proteomics : clinical applications. Weinheim: WILEY-VCH Verlag, 2012, vol. 6, 7-8, p. 351-363. ISSN 1862-8346. doi:10.1002/prca.201100104.
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Basic information
Original name Potential biomarkers for early detection of acute graft-versus-host disease
Authors LOCHMANOVÁ, Gabriela (203 Czech Republic, belonging to the institution), Lenka JEDLIČKOVÁ (203 Czech Republic, belonging to the institution), David POTĚŠIL (203 Czech Republic, belonging to the institution), Alexandra TOMANCOVÁ (203 Czech Republic, belonging to the institution), Jan VERNER (203 Czech Republic, belonging to the institution), Šárka POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution), Michael DOUBEK (203 Czech Republic, belonging to the institution), Jiří MAYER (203 Czech Republic, belonging to the institution) and Zbyněk ZDRÁHAL (203 Czech Republic, guarantor, belonging to the institution).
Edition Proteomics : clinical applications. Weinheim, WILEY-VCH Verlag, 2012, 1862-8346.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.925
RIV identification code RIV/00216224:14740/12:00064911
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1002/prca.201100104
UT WoS 000308093000005
Keywords in English BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; C-REACTIVE PROTEIN; SERUM CYTOKINE LEVELS; NECROSIS-FACTOR-ALPHA; ACUTE GVHD; SOLUBLE INTERLEUKIN-2-RECEPTOR; QUANTITATIVE PROTEOMICS; MAJOR COMPLICATIONS; PLASMA BIOMARKERS
Tags ok, podil, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 12/4/2013 04:05.
Abstract
Acute graft-versus-host disease (aGVHD) is the main complication of allogeneic hematopoietic stem cell transplantation (HCT), resulting in considerable morbidity and mortality. Currently, the diagnosis of aGVHD is largely made based on clinical parameters and invasive biopsies. For the past 20 years, researchers have been trying to find reliable biomarkers to enable early and accurate diagnosis of aGVHD. Although a number of potential aGVHD biomarkers have been published, as yet, no validated diagnostic test is available. Proteomics encompasses a broad range of rapidly developing technologies, which have shown tremendous promise for early detection of aGVHD. In this article, we review the current state of aGVHD biomarker discovery, provide a summary of the key proteins of interest and the most common analytical procedures for the clinic, as well as outlining the significant challenges faced in their use.
Links
NS9683, research and development projectName: Změny genomu a proteomu u leukemických pacientů s reakcí štěpu proti hostiteli (GvHD)
Investor: Ministry of Health of the CR
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