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@article{1074157,
author = {Lochmanová, Gabriela and Jedličková, Lenka and Potěšil, David and Tomancová, Alexandra and Verner, Jan and Pospíšilová, Šárka and Doubek, Michael and Mayer, Jiří and Zdráhal, Zbyněk},
article_location = {Weinheim},
article_number = {7-8},
doi = {http://dx.doi.org/10.1002/prca.201100104},
keywords = {BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; C-REACTIVE PROTEIN; SERUM CYTOKINE LEVELS; NECROSIS-FACTOR-ALPHA; ACUTE GVHD; SOLUBLE INTERLEUKIN-2-RECEPTOR; QUANTITATIVE PROTEOMICS; MAJOR COMPLICATIONS; PLASMA BIOMARKERS},
language = {eng},
issn = {1862-8346},
journal = {Proteomics : clinical applications.},
title = {Potential biomarkers for early detection of acute graft-versus-host disease},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22927351},
volume = {6},
year = {2012}
}
TY - JOUR
ID - 1074157
AU - Lochmanová, Gabriela - Jedličková, Lenka - Potěšil, David - Tomancová, Alexandra - Verner, Jan - Pospíšilová, Šárka - Doubek, Michael - Mayer, Jiří - Zdráhal, Zbyněk
PY - 2012
TI - Potential biomarkers for early detection of acute graft-versus-host disease
JF - Proteomics : clinical applications.
VL - 6
IS - 7-8
SP - 351-363
EP - 351-363
PB - WILEY-VCH Verlag
SN - 18628346
KW - BONE-MARROW-TRANSPLANTATION
KW - STEM-CELL TRANSPLANTATION
KW - C-REACTIVE PROTEIN
KW - SERUM CYTOKINE LEVELS
KW - NECROSIS-FACTOR-ALPHA
KW - ACUTE GVHD
KW - SOLUBLE INTERLEUKIN-2-RECEPTOR
KW - QUANTITATIVE PROTEOMICS
KW - MAJOR COMPLICATIONS
KW - PLASMA BIOMARKERS
UR - http://www.ncbi.nlm.nih.gov/pubmed/22927351
L2 - http://www.ncbi.nlm.nih.gov/pubmed/22927351
N2 - Acute graft-versus-host disease (aGVHD) is the main complication of allogeneic hematopoietic stem cell transplantation (HCT), resulting in considerable morbidity and mortality. Currently, the diagnosis of aGVHD is largely made based on clinical parameters and invasive biopsies. For the past 20 years, researchers have been trying to find reliable biomarkers to enable early and accurate diagnosis of aGVHD. Although a number of potential aGVHD biomarkers have been published, as yet, no validated diagnostic test is available. Proteomics encompasses a broad range of rapidly developing technologies, which have shown tremendous promise for early detection of aGVHD. In this article, we review the current state of aGVHD biomarker discovery, provide a summary of the key proteins of interest and the most common analytical procedures for the clinic, as well as outlining the significant challenges faced in their use.
ER -
LOCHMANOVÁ, Gabriela, Lenka JEDLIČKOVÁ, David POTĚŠIL, Alexandra TOMANCOVÁ, Jan VERNER, Šárka POSPÍŠILOVÁ, Michael DOUBEK, Jiří MAYER a Zbyněk ZDRÁHAL. Potential biomarkers for early detection of acute graft-versus-host disease. \textit{Proteomics : clinical applications.}. Weinheim: WILEY-VCH Verlag, 2012, roč.~6, 7-8, s.~351-363. ISSN~1862-8346. doi:10.1002/prca.201100104.
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