| SUK, Pavel, Ivan ČUNDRLE, Jan HRUDA, Lenka VOCÍLKOVÁ, Zdeněk KONEČNÝ, Michal VLAŠÍN, Martin MATĚJOVIČ, Martin PAVLÍK, Václav ZVONÍČEK and Vladimír ŠRÁMEK. Porcine model of ruptured abdominal aortic aneurysm repair. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. Londýn: W B SAUNDERS CO LTD, 2012, vol. 43, No 6, p. 698-704. ISSN 1078-5884. doi:10.1016/j.ejvs.2012.02.020. |
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@article{1074271,
author = {Suk, Pavel and Čundrle, Ivan and Hruda, Jan and Vocílková, Lenka and Konečný, Zdeněk and Vlašín, Michal and Matějovič, Martin and Pavlík, Martin and Zvoníček, Václav and Šrámek, Vladimír},
article_location = {Londýn},
article_number = {6},
doi = {http://dx.doi.org/10.1016/j.ejvs.2012.02.020},
keywords = {Ruptured aortic aneurysm; Haemorrhage; Intra-abdominal hypertension; Experimental},
language = {eng},
issn = {1078-5884},
journal = {EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY},
title = {Porcine model of ruptured abdominal aortic aneurysm repair},
volume = {43},
year = {2012}
}
TY - JOUR
ID - 1074271
AU - Suk, Pavel - Čundrle, Ivan - Hruda, Jan - Vocílková, Lenka - Konečný, Zdeněk - Vlašín, Michal - Matějovič, Martin - Pavlík, Martin - Zvoníček, Václav - Šrámek, Vladimír
PY - 2012
TI - Porcine model of ruptured abdominal aortic aneurysm repair
JF - EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
VL - 43
IS - 6
SP - 698-704
EP - 698-704
PB - W B SAUNDERS CO LTD
SN - 10785884
KW - Ruptured aortic aneurysm
KW - Haemorrhage
KW - Intra-abdominal hypertension
KW - Experimental
N2 - Objectives: To validate a porcine model of ruptured abdominal aortic aneurysm (rAAA) repair. Design: Experimental study. Methods: Ten experimental and five sham-operated pigs were studied. Instrumentation for cardiac output (CO) measurement, regional blood flow (renal-REN and portal-PORT) and blood sampling (inferior vena cava (IVC), renal and portal vein) was done. Microcirculation was visualised sublingually and in ileostoma. Protocol: simulation of rAAA with bleeding (mean arterial pressure (MAP) 45 mmHg) and increased abdominal pressure (25 mmHg) for 4 h; 2 h of infrarenal clamp with shed blood retransfusion; 11 h of post-surgery care. Results: Six experimental pigs completed the protocol and are presented. Bleeding decreased CO to 95%, PORT to 80% and REN to 10% of baseline. From clamping on CO and PORT increased above baseline whereas REN (47%) with creatinine clearance remained compromised till the end. Microcirculation was affected more in ileum than sublingually. Approximately threefold increase in cytokines (tumour necrosis factor-a (TNF-alpha), interleukin (IL)-6 and IL-10) and oxidative stress markers thiobarbituric acid-reactive substances (TBARs) and 4-hydroxy-2-trans-nonenal (HNE) was observed. Only mild increase in IL-6 and TBARs was observed in sham-operated animals. Organ histology did not reveal differences between groups. Conclusions: This near-lethal model of rAAA induced expected severe deterioration of haemodynamics and metabolism accompanied with a moderate inflammatory and oxidative stress response.
ER -
SUK, Pavel, Ivan ČUNDRLE, Jan HRUDA, Lenka VOCÍLKOVÁ, Zdeněk KONEČNÝ, Michal VLAŠÍN, Martin MATĚJOVIČ, Martin PAVLÍK, Václav ZVONÍČEK and Vladimír ŠRÁMEK. Porcine model of ruptured abdominal aortic aneurysm repair. \textit{EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY}. Londýn: W B SAUNDERS CO LTD, 2012, vol.~43, No~6, p.~698-704. ISSN~1078-5884. doi:10.1016/j.ejvs.2012.02.020.
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