SUK, Pavel, Ivan ČUNDRLE, Jan HRUDA, Lenka VOCÍLKOVÁ, Zdeněk KONEČNÝ, Michal VLAŠÍN, Martin MATĚJOVIČ, Martin PAVLÍK, Václav ZVONÍČEK and Vladimír ŠRÁMEK. Porcine model of ruptured abdominal aortic aneurysm repair. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. Londýn: W B SAUNDERS CO LTD, 2012, vol. 43, No 6, p. 698-704. ISSN 1078-5884. doi:10.1016/j.ejvs.2012.02.020. |
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@article{1074271, author = {Suk, Pavel and Čundrle, Ivan and Hruda, Jan and Vocílková, Lenka and Konečný, Zdeněk and Vlašín, Michal and Matějovič, Martin and Pavlík, Martin and Zvoníček, Václav and Šrámek, Vladimír}, article_location = {Londýn}, article_number = {6}, doi = {http://dx.doi.org/10.1016/j.ejvs.2012.02.020}, keywords = {Ruptured aortic aneurysm; Haemorrhage; Intra-abdominal hypertension; Experimental}, language = {eng}, issn = {1078-5884}, journal = {EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY}, title = {Porcine model of ruptured abdominal aortic aneurysm repair}, volume = {43}, year = {2012} }
TY - JOUR ID - 1074271 AU - Suk, Pavel - Čundrle, Ivan - Hruda, Jan - Vocílková, Lenka - Konečný, Zdeněk - Vlašín, Michal - Matějovič, Martin - Pavlík, Martin - Zvoníček, Václav - Šrámek, Vladimír PY - 2012 TI - Porcine model of ruptured abdominal aortic aneurysm repair JF - EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY VL - 43 IS - 6 SP - 698-704 EP - 698-704 PB - W B SAUNDERS CO LTD SN - 10785884 KW - Ruptured aortic aneurysm KW - Haemorrhage KW - Intra-abdominal hypertension KW - Experimental N2 - Objectives: To validate a porcine model of ruptured abdominal aortic aneurysm (rAAA) repair. Design: Experimental study. Methods: Ten experimental and five sham-operated pigs were studied. Instrumentation for cardiac output (CO) measurement, regional blood flow (renal-REN and portal-PORT) and blood sampling (inferior vena cava (IVC), renal and portal vein) was done. Microcirculation was visualised sublingually and in ileostoma. Protocol: simulation of rAAA with bleeding (mean arterial pressure (MAP) 45 mmHg) and increased abdominal pressure (25 mmHg) for 4 h; 2 h of infrarenal clamp with shed blood retransfusion; 11 h of post-surgery care. Results: Six experimental pigs completed the protocol and are presented. Bleeding decreased CO to 95%, PORT to 80% and REN to 10% of baseline. From clamping on CO and PORT increased above baseline whereas REN (47%) with creatinine clearance remained compromised till the end. Microcirculation was affected more in ileum than sublingually. Approximately threefold increase in cytokines (tumour necrosis factor-a (TNF-alpha), interleukin (IL)-6 and IL-10) and oxidative stress markers thiobarbituric acid-reactive substances (TBARs) and 4-hydroxy-2-trans-nonenal (HNE) was observed. Only mild increase in IL-6 and TBARs was observed in sham-operated animals. Organ histology did not reveal differences between groups. Conclusions: This near-lethal model of rAAA induced expected severe deterioration of haemodynamics and metabolism accompanied with a moderate inflammatory and oxidative stress response. ER -
SUK, Pavel, Ivan ČUNDRLE, Jan HRUDA, Lenka VOCÍLKOVÁ, Zdeněk KONEČNÝ, Michal VLAŠÍN, Martin MATĚJOVIČ, Martin PAVLÍK, Václav ZVONÍČEK and Vladimír ŠRÁMEK. Porcine model of ruptured abdominal aortic aneurysm repair. \textit{EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY}. Londýn: W B SAUNDERS CO LTD, 2012, vol.~43, No~6, p.~698-704. ISSN~1078-5884. doi:10.1016/j.ejvs.2012.02.020.
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