SUK, Pavel, Ivan ČUNDRLE, Jan HRUDA, Lenka VOCÍLKOVÁ, Zdeněk KONEČNÝ, Michal VLAŠÍN, Martin MATĚJOVIČ, Martin PAVLÍK, Václav ZVONÍČEK and Vladimír ŠRÁMEK. Porcine model of ruptured abdominal aortic aneurysm repair. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. Londýn: W B SAUNDERS CO LTD, 2012, vol. 43, No 6, p. 698-704. ISSN 1078-5884. doi:10.1016/j.ejvs.2012.02.020.
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Basic information
Original name Porcine model of ruptured abdominal aortic aneurysm repair
Authors SUK, Pavel (203 Czech Republic, guarantor, belonging to the institution), Ivan ČUNDRLE (203 Czech Republic, belonging to the institution), Jan HRUDA (203 Czech Republic, belonging to the institution), Lenka VOCÍLKOVÁ (203 Czech Republic, belonging to the institution), Zdeněk KONEČNÝ (203 Czech Republic, belonging to the institution), Michal VLAŠÍN (203 Czech Republic), Martin MATĚJOVIČ (203 Czech Republic), Martin PAVLÍK (203 Czech Republic, belonging to the institution), Václav ZVONÍČEK (203 Czech Republic, belonging to the institution) and Vladimír ŠRÁMEK (203 Czech Republic, belonging to the institution).
Edition EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Londýn, W B SAUNDERS CO LTD, 2012, 1078-5884.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.820
RIV identification code RIV/00216224:14110/12:00061980
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.ejvs.2012.02.020
UT WoS 000305441400019
Keywords in English Ruptured aortic aneurysm; Haemorrhage; Intra-abdominal hypertension; Experimental
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 10. 2. 2013 16:29.
Abstract
Objectives: To validate a porcine model of ruptured abdominal aortic aneurysm (rAAA) repair. Design: Experimental study. Methods: Ten experimental and five sham-operated pigs were studied. Instrumentation for cardiac output (CO) measurement, regional blood flow (renal-REN and portal-PORT) and blood sampling (inferior vena cava (IVC), renal and portal vein) was done. Microcirculation was visualised sublingually and in ileostoma. Protocol: simulation of rAAA with bleeding (mean arterial pressure (MAP) 45 mmHg) and increased abdominal pressure (25 mmHg) for 4 h; 2 h of infrarenal clamp with shed blood retransfusion; 11 h of post-surgery care. Results: Six experimental pigs completed the protocol and are presented. Bleeding decreased CO to 95%, PORT to 80% and REN to 10% of baseline. From clamping on CO and PORT increased above baseline whereas REN (47%) with creatinine clearance remained compromised till the end. Microcirculation was affected more in ileum than sublingually. Approximately threefold increase in cytokines (tumour necrosis factor-a (TNF-alpha), interleukin (IL)-6 and IL-10) and oxidative stress markers thiobarbituric acid-reactive substances (TBARs) and 4-hydroxy-2-trans-nonenal (HNE) was observed. Only mild increase in IL-6 and TBARs was observed in sham-operated animals. Organ histology did not reveal differences between groups. Conclusions: This near-lethal model of rAAA induced expected severe deterioration of haemodynamics and metabolism accompanied with a moderate inflammatory and oxidative stress response.
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