TOMAN, Ondřej, Tomáš NOVOTNÝ, Martina ŠIŠÁKOVÁ, Katerina HNATKOVA, Irena ANDRŠOVÁ, Jiří PAŘENICA, Martin POLOCZEK, Jarmila JENYSOVA, Lenka MANOUSKOVA, Jindřich ŠPINAR and Marek MALÍK. Effect of atorvastatin on dynamic parameters of myocardial repolarization in healthy subjects. Journal of Electrocardiology. PHILADELPHIA: CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS, 2012, vol. 45, No 6, p. 752–757. ISSN 0022-0736. doi:10.1016/j.jelectrocard.2012.06.020.
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Basic information
Original name Effect of atorvastatin on dynamic parameters of myocardial repolarization in healthy subjects
Authors TOMAN, Ondřej, Tomáš NOVOTNÝ, Martina ŠIŠÁKOVÁ, Katerina HNATKOVA, Irena ANDRŠOVÁ, Jiří PAŘENICA, Martin POLOCZEK, Jarmila JENYSOVA, Lenka MANOUSKOVA, Jindřich ŠPINAR and Marek MALÍK.
Edition Journal of Electrocardiology, PHILADELPHIA, CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS, 2012, 0022-0736.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.093
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.jelectrocard.2012.06.020
UT WoS 000310763300041
Keywords in English Atorvastatin; Myocardial repolarization; ECG
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 23. 4. 2014 13:51.
Abstract
Antiarrhythmic properties of statins were suggested as a part of their pleiotropic effects. The aim of the present study was to evaluate the effects of atorvastatin on myocardial repolarization as manifested on surface electrocardiograms (ECGs) in healthy subjects. Methods and Results: Forty young healthy volunteers (20 men, 20 women) underwent a singledose double-blind 3-way crossover study of 20 and 80 mg of atorvastatin and placebo. Long-term 13-hour 12-lead ECGs were obtained in each subject and each study period starting 15 minutes before drug administration. Each study period contained 18 time-points of 5-minute durations when the subjects were in resting supine positions. Digital ECG recordings were analyzed automatically, and the results were completed blindly before statistical analyses. Dynamic parameters of myocardial repolarization and T-wave morphology descriptors were evaluated. Although some trends were observed, no significant drug-related changes in any of investigated ECG repolarization descriptors were found. Conclusion: In comparison with placebo, single doses of atorvastatin had no effect on repolarization heterogeneity in healthy subjects. The observation confirms safe profile of the drug with limited proarrhythmic potential.
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