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@article{1075115,
author = {Litzman, Jiří and Nechvátalová, Jana and Xu, J. and Tichá, Olga and Vlková, Marcela and Hel, Z.},
article_number = {3},
doi = {http://dx.doi.org/10.1111/j.1365-2249.2012.04655.x},
keywords = {common variable immunodeficiency; endotoxin; IgA deficiency; lymphocyte activation},
language = {eng},
issn = {0009-9104},
journal = {Clinical & Experimental Immunology},
title = {Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia},
volume = {170},
year = {2012}
}
TY - JOUR
ID - 1075115
AU - Litzman, Jiří - Nechvátalová, Jana - Xu, J. - Tichá, Olga - Vlková, Marcela - Hel, Z.
PY - 2012
TI - Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia
JF - Clinical & Experimental Immunology
VL - 170
IS - 3
SP - 321-332
EP - 321-332
PB - WILEY-BLACKWELL
SN - 00099104
KW - common variable immunodeficiency
KW - endotoxin
KW - IgA deficiency
KW - lymphocyte activation
N2 - Common variable immunodeficiency (CVID), the most frequent symptomatic immunoglobulin primary immunodeficiency, is associated with chronic T cell activation and reduced frequency of CD4+ T cells. The underlying cause of immune activation in CVID is unknown. Microbial translocation indicated by elevated serum levels of lipopolysaccharide and soluble CD14 (sCD14) has been linked previously to systemic immune activation in human immunodeficiency virus/acquired immune deficiency syndrome (HIV-1/AIDS), alcoholic cirrhosis and other conditions. To address the mechanisms of chronic immune activation in CVID, we performed a detailed analysis of immune cell populations and serum levels of sCD14, soluble CD25 (sCD25), lipopolysaccharide and markers of liver function in 35 patients with CVID, 53 patients with selective immunoglobulin (Ig)A deficiency (IgAD) and 63 control healthy subjects. In CVID subjects, the concentration of serum sCD14 was increased significantly and correlated with the level of sCD25, C-reactive protein and the extent of T cell activation. Importantly, no increase in serum lipopolysaccharide concentration was observed in patients with CVID or IgAD. Collectively, the data presented suggest that chronic T cell activation in CVID is associated with elevated levels of sCD14 and sCD25, but not with systemic endotoxaemia, and suggest involvement of lipopolysaccharide-independent mechanisms of induction of sCD14 production.
ER -
LITZMAN, Jiří, Jana NECHVÁTALOVÁ, J. XU, Olga TICHÁ, Marcela VLKOVÁ and Z. HEL. Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia. \textit{Clinical \&{} Experimental Immunology}. WILEY-BLACKWELL, vol.~170, No~3, p.~321-332. ISSN~0009-9104. doi:10.1111/j.1365-2249.2012.04655.x. 2012.
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