LITZMAN, Jiří, Jana NECHVÁTALOVÁ, J. XU, Olga TICHÁ, Marcela VLKOVÁ and Z. HEL. Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia. Clinical & Experimental Immunology. WILEY-BLACKWELL, 2012, vol. 170, No 3, p. 321-332. ISSN 0009-9104. doi:10.1111/j.1365-2249.2012.04655.x.
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Basic information
Original name Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia
Authors LITZMAN, Jiří (203 Czech Republic, guarantor, belonging to the institution), Jana NECHVÁTALOVÁ (203 Czech Republic, belonging to the institution), J. XU (840 United States of America), Olga TICHÁ (203 Czech Republic, belonging to the institution), Marcela VLKOVÁ (203 Czech Republic, belonging to the institution) and Z. HEL (840 United States of America).
Edition Clinical & Experimental Immunology, WILEY-BLACKWELL, 2012, 0009-9104.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30102 Immunology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.409
RIV identification code RIV/00216224:14110/12:00062051
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1111/j.1365-2249.2012.04655.x
UT WoS 000310550500009
Keywords in English common variable immunodeficiency; endotoxin; IgA deficiency; lymphocyte activation
Tags International impact
Changed by Changed by: Mgr. Michal Petr, učo 65024. Changed: 5/12/2012 08:32.
Abstract
Common variable immunodeficiency (CVID), the most frequent symptomatic immunoglobulin primary immunodeficiency, is associated with chronic T cell activation and reduced frequency of CD4+ T cells. The underlying cause of immune activation in CVID is unknown. Microbial translocation indicated by elevated serum levels of lipopolysaccharide and soluble CD14 (sCD14) has been linked previously to systemic immune activation in human immunodeficiency virus/acquired immune deficiency syndrome (HIV-1/AIDS), alcoholic cirrhosis and other conditions. To address the mechanisms of chronic immune activation in CVID, we performed a detailed analysis of immune cell populations and serum levels of sCD14, soluble CD25 (sCD25), lipopolysaccharide and markers of liver function in 35 patients with CVID, 53 patients with selective immunoglobulin (Ig)A deficiency (IgAD) and 63 control healthy subjects. In CVID subjects, the concentration of serum sCD14 was increased significantly and correlated with the level of sCD25, C-reactive protein and the extent of T cell activation. Importantly, no increase in serum lipopolysaccharide concentration was observed in patients with CVID or IgAD. Collectively, the data presented suggest that chronic T cell activation in CVID is associated with elevated levels of sCD14 and sCD25, but not with systemic endotoxaemia, and suggest involvement of lipopolysaccharide-independent mechanisms of induction of sCD14 production.
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