Informační systém MU
LITZMAN, Jiří, Jana NECHVÁTALOVÁ, J. XU, Olga TICHÁ, Marcela VLKOVÁ a Z. HEL. Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia. Clinical & Experimental Immunology. WILEY-BLACKWELL, 2012, roč. 170, č. 3, s. 321-332. ISSN 0009-9104. doi:10.1111/j.1365-2249.2012.04655.x.
Další formáty:   BibTeX LaTeX RIS
Základní údaje
Originální název Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia
Autoři LITZMAN, Jiří (203 Česká republika, garant, domácí), Jana NECHVÁTALOVÁ (203 Česká republika, domácí), J. XU (840 Spojené státy), Olga TICHÁ (203 Česká republika, domácí), Marcela VLKOVÁ (203 Česká republika, domácí) a Z. HEL (840 Spojené státy).
Vydání Clinical & Experimental Immunology, WILEY-BLACKWELL, 2012, 0009-9104.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30102 Immunology
Stát vydavatele Velká Británie
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 3.409
Kód RIV RIV/00216224:14110/12:00062051
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1111/j.1365-2249.2012.04655.x
UT WoS 000310550500009
Klíčová slova anglicky common variable immunodeficiency; endotoxin; IgA deficiency; lymphocyte activation
Příznaky Mezinárodní význam
Změnil Změnil: Mgr. Michal Petr, učo 65024. Změněno: 5. 12. 2012 08:32.
Anotace
Common variable immunodeficiency (CVID), the most frequent symptomatic immunoglobulin primary immunodeficiency, is associated with chronic T cell activation and reduced frequency of CD4+ T cells. The underlying cause of immune activation in CVID is unknown. Microbial translocation indicated by elevated serum levels of lipopolysaccharide and soluble CD14 (sCD14) has been linked previously to systemic immune activation in human immunodeficiency virus/acquired immune deficiency syndrome (HIV-1/AIDS), alcoholic cirrhosis and other conditions. To address the mechanisms of chronic immune activation in CVID, we performed a detailed analysis of immune cell populations and serum levels of sCD14, soluble CD25 (sCD25), lipopolysaccharide and markers of liver function in 35 patients with CVID, 53 patients with selective immunoglobulin (Ig)A deficiency (IgAD) and 63 control healthy subjects. In CVID subjects, the concentration of serum sCD14 was increased significantly and correlated with the level of sCD25, C-reactive protein and the extent of T cell activation. Importantly, no increase in serum lipopolysaccharide concentration was observed in patients with CVID or IgAD. Collectively, the data presented suggest that chronic T cell activation in CVID is associated with elevated levels of sCD14 and sCD25, but not with systemic endotoxaemia, and suggest involvement of lipopolysaccharide-independent mechanisms of induction of sCD14 production.
Zobrazeno: 15. 4. 2021 18:49