Chronic immune activation in common variable immunodeficiency
(CVID) is associated with elevated serum levels of soluble CD14
and CD25 but not endotoxaemia

J 2012

Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia

LITZMAN, Jiří, Jana NECHVÁTALOVÁ, J. XU, Olga TICHÁ, Marcela VLKOVÁ et. al.

Basic information

Original name

Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia

Authors

LITZMAN, Jiří (203 Czech Republic, guarantor, belonging to the institution), Jana NECHVÁTALOVÁ (203 Czech Republic, belonging to the institution), J. XU (840 United States of America), Olga TICHÁ (203 Czech Republic, belonging to the institution), Marcela VLKOVÁ (203 Czech Republic, belonging to the institution) and Z. HEL (840 United States of America)

Edition

Clinical & Experimental Immunology, WILEY-BLACKWELL, 2012, 0009-9104

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.409

RIV identification code

RIV/00216224:14110/12:00062051

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1111/j.1365-2249.2012.04655.x

UT WoS

000310550500009

Keywords in English

common variable immunodeficiency; endotoxin; IgA deficiency; lymphocyte activation

Abstract

V originále

Common variable immunodeficiency (CVID), the most frequent symptomatic immunoglobulin primary immunodeficiency, is associated with chronic T cell activation and reduced frequency of CD4+ T cells. The underlying cause of immune activation in CVID is unknown. Microbial translocation indicated by elevated serum levels of lipopolysaccharide and soluble CD14 (sCD14) has been linked previously to systemic immune activation in human immunodeficiency virus/acquired immune deficiency syndrome (HIV-1/AIDS), alcoholic cirrhosis and other conditions. To address the mechanisms of chronic immune activation in CVID, we performed a detailed analysis of immune cell populations and serum levels of sCD14, soluble CD25 (sCD25), lipopolysaccharide and markers of liver function in 35 patients with CVID, 53 patients with selective immunoglobulin (Ig)A deficiency (IgAD) and 63 control healthy subjects. In CVID subjects, the concentration of serum sCD14 was increased significantly and correlated with the level of sCD25, C-reactive protein and the extent of T cell activation. Importantly, no increase in serum lipopolysaccharide concentration was observed in patients with CVID or IgAD. Collectively, the data presented suggest that chronic T cell activation in CVID is associated with elevated levels of sCD14 and sCD25, but not with systemic endotoxaemia, and suggest involvement of lipopolysaccharide-independent mechanisms of induction of sCD14 production.

Citovat

LITZMAN, Jiří, Jana NECHVÁTALOVÁ, J. XU, Olga TICHÁ, Marcela VLKOVÁ and Z. HEL. Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia. Clinical & Experimental Immunology. WILEY-BLACKWELL, 2012, vol. 170, No 3, p. 321-332. ISSN 0009-9104. Available from: https://dx.doi.org/10.1111/j.1365-2249.2012.04655.x.

@article{1075115,
   author = {Litzman, Jiří and Nechvátalová, Jana and Xu, J. and Tichá, Olga and Vlková, Marcela and Hel, Z.},
   article_number = {3},
   doi = {http://dx.doi.org/10.1111/j.1365-2249.2012.04655.x},
   keywords = {common variable immunodeficiency; endotoxin; IgA deficiency; lymphocyte activation},
   language = {eng},
   issn = {0009-9104},
   journal = {Clinical & Experimental Immunology},
   title = {Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia},
   volume = {170},
   year = {2012}
}

TY  - JOUR
ID  - 1075115
AU  - Litzman, Jiří - Nechvátalová, Jana - Xu, J. - Tichá, Olga - Vlková, Marcela - Hel, Z.
PY  - 2012
TI  - Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia
JF  - Clinical & Experimental Immunology
VL  - 170
IS  - 3
SP  - 321-332
EP  - 321-332
PB  - WILEY-BLACKWELL
SN  - 00099104
KW  - common variable immunodeficiency
KW  - endotoxin
KW  - IgA deficiency
KW  - lymphocyte activation
N2  - Common variable immunodeficiency (CVID), the most frequent symptomatic immunoglobulin primary immunodeficiency, is associated with chronic T cell activation and reduced frequency of CD4+ T cells. The underlying cause of immune activation in CVID is unknown. Microbial translocation indicated by elevated serum levels of lipopolysaccharide and soluble CD14 (sCD14) has been linked previously to systemic immune activation in human immunodeficiency virus/acquired immune deficiency syndrome (HIV-1/AIDS), alcoholic cirrhosis and other conditions. To address the mechanisms of chronic immune activation in CVID, we performed a detailed analysis of immune cell populations and serum levels of sCD14, soluble CD25 (sCD25), lipopolysaccharide and markers of liver function in 35 patients with CVID, 53 patients with selective immunoglobulin (Ig)A deficiency (IgAD) and 63 control healthy subjects. In CVID subjects, the concentration of serum sCD14 was increased significantly and correlated with the level of sCD25, C-reactive protein and the extent of T cell activation. Importantly, no increase in serum lipopolysaccharide concentration was observed in patients with CVID or IgAD. Collectively, the data presented suggest that chronic T cell activation in CVID is associated with elevated levels of sCD14 and sCD25, but not with systemic endotoxaemia, and suggest involvement of lipopolysaccharide-independent mechanisms of induction of sCD14 production.
ER  -

LITZMAN, Jiří, Jana NECHVÁTALOVÁ, J. XU, Olga TICHÁ, Marcela VLKOVÁ and Z. HEL. Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia. \textit{Clinical \&{} Experimental Immunology}. WILEY-BLACKWELL, 2012, vol.~170, No~3, p.~321-332. ISSN~0009-9104. Available from: https://dx.doi.org/10.1111/j.1365-2249.2012.04655.x.

Detailed Information on Publication Record