ŠMAJS, David, Steven J. NORRIS and George M. WEINSTOCK. Genetic diversity in Treponema pallidum: Implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws. Infection, Genetics and Evolution. AMSTERDAM: ELSEVIER SCIENCE BV, 2012, vol. 12, No 2, p. 191-202. ISSN 1567-1348. doi:10.1016/j.meegid.2011.12.001.
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Original name Genetic diversity in Treponema pallidum: Implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws
Authors ŠMAJS, David (203 Czech Republic, guarantor, belonging to the institution), Steven J. NORRIS (840 United States of America) and George M. WEINSTOCK (840 United States of America).
Edition Infection, Genetics and Evolution, AMSTERDAM, ELSEVIER SCIENCE BV, 2012, 1567-1348.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.768
RIV identification code RIV/00216224:14110/12:00057855
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.meegid.2011.12.001
UT WoS 000302512100002
Keywords in English Treponema pallidum; Treponema pallidum ssp pertenue; Treponema pallidum ssp endemicum; Treponema paraluiscuniculi; Whole genome sequencing; Molecular evolution; Molecular diagnostics
Tags International impact
Changed by Changed by: Mgr. Michal Petr, učo 65024. Changed: 28. 11. 2012 11:36.
Abstract
Pathogenic uncultivable treponemes, similar to syphilis-causing Treponema pallidum subspecies pallidum, include T. pallidum ssp. pertenue, T. pallidum ssp. endemicum and Treponema carateum, which cause yaws, bejel and pinta, respectively. Genetic analyses of these pathogens revealed striking similarity among these bacteria and also a high degree of similarity to the rabbit pathogen, Treponema paraluiscuniculi, a treponeme not infectious to humans. Genome comparisons between pallidum and non-pallidum treponemes revealed genes with potential involvement in human infectivity, whereas comparisons between pallidum and pertenue treponemes identified genes possibly involved in the high invasivity of syphilis treponemes. Genetic variability within syphilis strains is considered as the basis of syphilis molecular epidemiology with potential to detect more virulent strains, whereas genetic variability within a single strain is related to its ability to elude the immune system of the host. Genome analyses also shed light on treponemal evolution and on chromosomal targets for molecular diagnostics of treponemal infections. (C) 2011 Elsevier B.V. All rights reserved.
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GA310/04/0021, research and development projectName: Postgenomické studie syfilitické spirochety Treponema pallidum
Investor: Czech Science Foundation, Standard Projects
MSM0021622415, plan (intention)Name: Molekulární podstata buněčných a tkáňových regulací
Investor: Ministry of Education, Youth and Sports of the CR, Research Intents
NT11159, research and development projectName: Mapování výskytu makrolidové rezistence původce syfilis v ČR a molekulární typizace jednotlivých syfilitických kmenů
Investor: Ministry of Health of the CR
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