Detailed Information on Publication Record
2012
Novel Colicin F-Y of Yersinia frederiksenii Inhibits Pathogenic Yersinia Strains via YiuR-Mediated Reception, TonB Import, and Cell Membrane Pore Formation
BOSÁK, Juraj, Petra LAIBLOVA, Jan ŠMARDA, Daniela DĚDIČOVÁ, David ŠMAJS et. al.Basic information
Original name
Novel Colicin F-Y of Yersinia frederiksenii Inhibits Pathogenic Yersinia Strains via YiuR-Mediated Reception, TonB Import, and Cell Membrane Pore Formation
Authors
BOSÁK, Juraj (703 Slovakia, guarantor, belonging to the institution), Petra LAIBLOVA (203 Czech Republic), Jan ŠMARDA (203 Czech Republic, belonging to the institution), Daniela DĚDIČOVÁ (203 Czech Republic) and David ŠMAJS (203 Czech Republic, belonging to the institution)
Edition
Journal of Bacteriology, WASHINGTON, AMER SOC MICROBIOLOGY, 2012, 0021-9193
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10600 1.6 Biological sciences
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 3.177
RIV identification code
RIV/00216224:14110/12:00064916
Organization unit
Faculty of Medicine
UT WoS
000302180200012
Keywords in English
HUMAN ESCHERICHIA-COLI; SON-KILLER BACTERIUM; SP-NOV; OUTER-MEMBRANE; ARSENOPHONUS-NASONIAE; SERRATIA-MARCESCENS; NUCLEOTIDE-SEQUENCE; VIRULENCE FACTOR; GENOME SEQUENCE; PESTICIN
Tags
International impact
Změněno: 21/3/2017 15:14, Ing. Mgr. Věra Pospíšilíková
Abstract
V originále
A novel colicin type, designated colicin F-Y, was found to be encoded and produced by the strain Yersinia frederiksenii Y27601. Colicin F-Y was active against both pathogenic and nonpathogenic strains of the genus Yersinia. Plasmid YF27601 (5,574 bp) of Y. frederiksenii Y27601 was completely sequenced. The colicin F-Y activity gene (cfyA) and the colicin F-Y immunity gene (cfyI) were identified. The deduced amino acid sequence of colicin F-Y was very similar in its C-terminal pore-forming domain to colicin Ib (69% identity in the last 178 amino acid residues), indicating pore forming as its lethal mode of action. Transposon mutagenesis of the colicin F-Y-susceptible strain Yersinia kristensenii Y276 revealed the yiuR gene (ykris001_4440), which encodes the YiuR outer membrane protein with unknown function, as the colicin F-Y receptor molecule. Introduction of the yiuR gene into the colicin F-Y-resistant strain Y. kristensenii Y104 restored its susceptibility to colicin F-Y. In contrast, the colicin F-Y-resistant strain Escherichia coli TOP10F' acquired susceptibility to colicin F-Y only when both the yiuR and tonB genes from Y. kristensenii Y276 were introduced. Similarities between colicins F-Y and Ib, similarities between the Cir and YiuR receptors, and the detected partial cross-immunity of colicin F-Y and colicin Ib producers suggest a common evolutionary origin of the colicin F-Y-YiuR and colicin Ib-Cir systems.
Links
| NS9665, research and development project |
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