The 5th MEFANET Conference took place on 24–25 November 2011 on the premises of Voronez Hotel in Brno, Czech Republic. This annual meeting of representatives from all Czech and Slovak medical faculties is focused on the issues of e-learning and health informatics in the education of medical disciplines. Conference participants had again the opportunity to learn about the latest trends in electronic tools employed in the education of future doctors in the Czech Republic and Slovakia, as well as about the latest developments in the MEFANET (MEdical FAculties NETwork) project.