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D ASCENZO, Fabrizio, Erika CAVALLERO, Claudio MORETTI, Pierluigi OMEDE, Filippo SCIUTO, Ishtiaq A. RAHMAN, Robert S. BONSER, Jeon YUNSEOK, Robert WAGNER, Tomáš FREIBERGER, Gudrun KUNST, Michael S. MARBER, Matthias THIELMANN, Bingyang JI, Yasser M. AMR, Maria Grazia MODENA, Giuseppe Biondi ZOCCAI, Imad SHEIBAN and Fiorenzo GAITA. Remote ischaemic preconditioning in coronary artery bypass surgery: a meta-analysis. Heart. London: BMJ Publishing Group, 2012, vol. 98, No 17, p. 1267-1271. ISSN 1355-6037. doi:10.1136/heartjnl-2011-301551.
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Basic information
Original name Remote ischaemic preconditioning in coronary artery bypass surgery: a meta-analysis
Authors D ASCENZO, Fabrizio (380 Italy), Erika CAVALLERO (380 Italy), Claudio MORETTI (380 Italy), Pierluigi OMEDE (380 Italy), Filippo SCIUTO (380 Italy), Ishtiaq A. RAHMAN (826 United Kingdom of Great Britain and Northern Ireland), Robert S. BONSER (826 United Kingdom of Great Britain and Northern Ireland), Jeon YUNSEOK (408 Democratic People's Republic of Korea), Robert WAGNER (203 Czech Republic), Tomáš FREIBERGER (203 Czech Republic, guarantor, belonging to the institution), Gudrun KUNST (826 United Kingdom of Great Britain and Northern Ireland), Michael S. MARBER (826 United Kingdom of Great Britain and Northern Ireland), Matthias THIELMANN (276 Germany), Bingyang JI (156 China), Yasser M. AMR (818 Egypt), Maria Grazia MODENA (380 Italy), Giuseppe Biondi ZOCCAI (380 Italy), Imad SHEIBAN (380 Italy) and Fiorenzo GAITA (380 Italy).
Edition Heart, London, BMJ Publishing Group, 2012, 1355-6037.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 5.014
RIV identification code RIV/00216224:14740/12:00062187
Organization unit Central European Institute of Technology
UT WoS 000307565800004
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 6. 4. 2013 06:05.
Aim Randomised trials exploring remote ischaemic preconditioning (RIPC) in patients undergoing coronary artery bypass graft (CABG) surgery have yielded conflicting data regarding potential cardiovascular and renal protection, and are individually flawed by small sample size. Methods Three investigators independently searched the MEDLINE, EMBASE and Cochrane databases to identify randomised trials testing RIPC in patients undergoing CABG. Results Nine studies with 704 patients were included. Standardised mean difference of troponin I and T release showed a significant decrease (-0.36 (95% CI -0.62 to -0.09)). This difference held true after excluding the trials with cross-clamp fibrillation, the study with off-pump CABG and studies using a flurane as anaesthetic agent (-0.41 (95% CI -0.69 to -0.12), -0.38 (95% CI -0.70 to -0.07) and -0.37 (95% CI -0.63 to -0.12), respectively). A similar trend was also obtained for patients with multivessel disease (-0.41 (95% CI -0.73 to -0.08)). The trials evaluating postoperative creatinine reported a non-significant reduction (0.02 (95% CI -0.09 to 0.13)). Moreover, the length of in-hospital stay was not influenced by the kind of treatment (weighted mean difference 0.27 (95% CI -0.24 to 0.79)). Conclusion RIPC reduced the release of troponin in patients undergoing CABG. Larger randomised trials are needed to clarify the presence of a causal relationship between RIPC-induced troponin release and clinical adverse events.
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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