J 2012

Homologous recombination and its regulation

KREJČÍ, Lumír; Veronika ALTMANNOVÁ; Mário ŠPÍREK and Xiaolan ZHAO

Basic information

Original name

Homologous recombination and its regulation

Authors

KREJČÍ, Lumír (203 Czech Republic, guarantor, belonging to the institution); Veronika ALTMANNOVÁ (203 Czech Republic, belonging to the institution); Mário ŠPÍREK (703 Slovakia, belonging to the institution) and Xiaolan ZHAO (840 United States of America)

Edition

Nucleic Acids Research, Oxford, UK, Oxford Press, 2012, 0305-1048

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

Genetics and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

is not subject to a state or trade secret

Impact factor

Impact factor: 8.278

RIV identification code

RIV/00216224:14110/12:00057915

Organization unit

Faculty of Medicine

DOI

UT WoS

000306970700009

Keywords in English

DOUBLE-STRAND-BREAK; REPLICATION PROTEIN-A; DNA-DAMAGE RESPONSE; RAD51 NUCLEOPROTEIN FILAMENTS; SACCHAROMYCES-CEREVISIAE SRS2; CANCER SUSCEPTIBILITY GENE; BLOOMS-SYNDROME HELICASE; JOINT MOLECULE FORMATION; ESCHERICHIA-COLI RECA; HUMAN BRCA2 PROTEIN

Tags

International impact
Changed: 11/12/2012 22:26, Mgr. Michal Petr

Abstract

V originále

Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for chromosomal pairing and exchange during meiosis. However, some forms of HR can also lead to undesirable DNA rearrangements. Multiple regulatory mechanisms have evolved to ensure that HR takes place at the right time, place and manner. Several of these impinge on the control of Rad51 nucleofilaments that play a central role in HR. Some factors promote the formation of these structures while others lead to their disassembly or the use of alternative repair pathways. In this article, we review these mechanisms in both mitotic and meiotic environments and in different eukaryotic taxa, with an emphasis on yeast and mammal systems. Since mutations in several proteins that regulate Rad51 nucleofilaments are associated with cancer and cancer-prone syndromes, we discuss how understanding their functions can lead to the development of better tools for cancer diagnosis and therapy.

Links

GAP207/12/2323, research and development project
Name: Endonuleazová a translokázová aktivita v restričních-modifikáčních komplexéch typu I
Investor: Czech Science Foundation
GA301/09/1917, research and development project
Name: Štěpení replikačních-rekombinačních DNA meziproduktů a jejich úloha při nestabilitě genomu
Investor: Czech Science Foundation
GD203/09/H046, research and development project
Name: Biochemie na rozcestí mezi in silico a in vitro
Investor: Czech Science Foundation
LC06030, research and development project
Name: Biomolekulární centrum
Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular centre
ME10048, research and development project
Name: Vliv post-translačních modifikací na DNA opravu a rekombinaci.
Investor: Ministry of Education, Youth and Sports of the CR, Research and Development Programme KONTAKT (ME)