KREJČÍ, Lumír, Veronika ALTMANNOVÁ, Mário ŠPÍREK and Xiaolan ZHAO. Homologous recombination and its regulation. Nucleic Acids Research. Oxford, UK: Oxford Press, 2012, vol. 40, No 13, p. 5795-5818. ISSN 0305-1048. doi:10.1093/nar/gks270.
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Basic information
Original name Homologous recombination and its regulation
Authors KREJČÍ, Lumír (203 Czech Republic, guarantor, belonging to the institution), Veronika ALTMANNOVÁ (203 Czech Republic, belonging to the institution), Mário ŠPÍREK (703 Slovakia, belonging to the institution) and Xiaolan ZHAO (840 United States of America).
Edition Nucleic Acids Research, Oxford, UK, Oxford Press, 2012, 0305-1048.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 8.278
RIV identification code RIV/00216224:14110/12:00057915
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1093/nar/gks270
UT WoS 000306970700009
Keywords in English DOUBLE-STRAND-BREAK; REPLICATION PROTEIN-A; DNA-DAMAGE RESPONSE; RAD51 NUCLEOPROTEIN FILAMENTS; SACCHAROMYCES-CEREVISIAE SRS2; CANCER SUSCEPTIBILITY GENE; BLOOMS-SYNDROME HELICASE; JOINT MOLECULE FORMATION; ESCHERICHIA-COLI RECA; HUMAN BRCA2 PROTEIN
Tags International impact
Changed by Changed by: Mgr. Michal Petr, učo 65024. Changed: 11/12/2012 22:26.
Abstract
Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for chromosomal pairing and exchange during meiosis. However, some forms of HR can also lead to undesirable DNA rearrangements. Multiple regulatory mechanisms have evolved to ensure that HR takes place at the right time, place and manner. Several of these impinge on the control of Rad51 nucleofilaments that play a central role in HR. Some factors promote the formation of these structures while others lead to their disassembly or the use of alternative repair pathways. In this article, we review these mechanisms in both mitotic and meiotic environments and in different eukaryotic taxa, with an emphasis on yeast and mammal systems. Since mutations in several proteins that regulate Rad51 nucleofilaments are associated with cancer and cancer-prone syndromes, we discuss how understanding their functions can lead to the development of better tools for cancer diagnosis and therapy.
Links
GAP207/12/2323, research and development projectName: Endonuleazová a translokázová aktivita v restričních-modifikáčních komplexéch typu I
Investor: Czech Science Foundation, Standard Projects
GA301/09/1917, research and development projectName: Štěpení replikačních-rekombinačních DNA meziproduktů a jejich úloha při nestabilitě genomu
Investor: Czech Science Foundation, Standard Projects
GD203/09/H046, research and development projectName: Biochemie na rozcestí mezi in silico a in vitro
Investor: Czech Science Foundation, Doctor grants
LC06030, research and development projectName: Biomolekulární centrum
Investor: Ministry of Education, Youth and Sports of the CR, Basic Research Center
ME10048, research and development projectName: Vliv post-translačních modifikací na DNA opravu a rekombinaci.
Investor: Ministry of Education, Youth and Sports of the CR, Programme KONTAKT (ME+MEB), Research and Development Programme KONTAKT (ME)
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