CHALUPOVÁ, Lenka, Alena ŽÁKOVSKÁ and K. ADAMCOVÁ. Development of a novel enzyme-linked immunosorbent assay (ELISA) for measurement of serum CTRP1 A pilot study: Measurement of serum CTRP1 in healthy donors and patients with metabolic syndrome. Clinical Biochemistry. ELSEVIER, vol. 46, 1-2, p. 73-78. ISSN 0009-9120. doi:10.1016/j.clinbiochem.2012.09.006. 2013.
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Basic information
Original name Development of a novel enzyme-linked immunosorbent assay (ELISA) for measurement of serum CTRP1 A pilot study: Measurement of serum CTRP1 in healthy donors and patients with metabolic syndrome
Authors CHALUPOVÁ, Lenka (203 Czech Republic, belonging to the institution), Alena ŽÁKOVSKÁ (203 Czech Republic, guarantor, belonging to the institution) and K. ADAMCOVÁ (203 Czech Republic).
Edition Clinical Biochemistry, ELSEVIER, 2013, 0009-9120.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30102 Immunology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.229
RIV identification code RIV/00216224:14310/13:00067579
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1016/j.clinbiochem.2012.09.006
UT WoS 000313406800016
Keywords in English ELISA CTRP1 Obesity Hypertension Adipokine Metabolic syndrome
Tags AKR, rivok, ZR
Changed by Changed by: Ing. Zdeňka Rašková, učo 140529. Changed: 25/4/2014 14:15.
Abstract
Background: Complement C1q tumor necrosis factor-related protein 1 (CTRP1), a recently identified adipokine, was found to stimulate aldosterone production. Obesity and metabolic syndrome are frequently associated with elevated levels of aldosterone. Therefore, it would be interesting to investigate whether the secretion of CTRP1 in human serum is associated with obesity as well as with hypertension. Aim: This study evaluated serum CTRP1 concentrations in healthy individuals and patients with metabolic syndrome. Methods: Serum samples from 61 healthy individuals and 46 patients with metabolic syndrome were measured for CTRP1 by enzyme-linked immunosorbent assay (ELISA). Results: Correlation analyses showed that serum CTRP1 in healthy individuals did not correlate with BMI, leptin, TG, HDL-CH, and LDL-CH; however, in patients with metabolic syndrome, CTRP1 correlated with glucose, HbA1c and BMI. CTRP1 level was significantly higher in subjects with metabolic syndrome compared to healthy subjects. Discussion: Our results support the hypothesis that adipokine CTRP1 is associated with metabolic syndrome and obesity compared to healthy individuals.
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