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@article{1079734,
author = {Felšőci, Marián and Pařenica, Jiří and Špinar, Jindřich and Vítovec, Jiří and Widimský, Petr and Linhart, Ales and Vaclavik, Jan and Málek, Filip and Bambuch, Miroslav and Miklík, Roman and Špinarová, Lenka and Bělohlávek, Jan and Čihalík, Čestmír and Jarkovský, Jiří},
article_location = {BRUSSELS},
article_number = {5},
doi = {http://dx.doi.org/10.2143/AC.67.5.2174125},
keywords = {Hypertension; pulmonary oedema; cardiogenic shock; heart failure; survival},
language = {eng},
issn = {0001-5385},
journal = {ACTA CARDIOLOGICA},
title = {Impact of antecedent hypertension on outcomes in patients hospitalized with severe forms of acute heart failure},
volume = {67},
year = {2012}
}
TY - JOUR
ID - 1079734
AU - Felšőci, Marián - Pařenica, Jiří - Špinar, Jindřich - Vítovec, Jiří - Widimský, Petr - Linhart, Ales - Vaclavik, Jan - Málek, Filip - Bambuch, Miroslav - Miklík, Roman - Špinarová, Lenka - Bělohlávek, Jan - Čihalík, Čestmír - Jarkovský, Jiří
PY - 2012
TI - Impact of antecedent hypertension on outcomes in patients hospitalized with severe forms of acute heart failure
JF - ACTA CARDIOLOGICA
VL - 67
IS - 5
SP - 515-523
EP - 515-523
PB - ACTA CARDIOLOGICA
SN - 00015385
KW - Hypertension
KW - pulmonary oedema
KW - cardiogenic shock
KW - heart failure
KW - survival
N2 - Objective Even though several studies described a positive influence of elevated initial blood pressure on the outcome in acute heart failure (AHF), data specifically addressed to a population with severe AHF associated with antecedent hypertension, regardless of admission blood pressure values, are missing. Methods and results From the 4153 consecutive patients enrolled in the Czech AHF registry we selected 1343 patients who suffered from pulmonary oedema or cardiogenic shock and compared them according to the presence of antecedent hypertension. Demographic, clinical, laboratory, treatment profiles and mortality rates were assessed and predictors of short- and long-term outcome were identified. Patients with antecedent hypertension (n = 1053, 78%) were older (P < 0.001), more often women (P. 0.001), having more co-morbidities and a worse laboratory profile. A trend for worse survival of hypertensive patients was observed when compared to a non-hypertensive cohort (1-, 2-, 3-year survival 70.0, 61.5, 55.5% vs. 72.6, 68.2, 64.0%, P = 0.062). Age and creatinine levels were independently associated with mortality during the whole follow-up period (P < 0.001). Low left ventricular ejection fraction, need of mechanical ventilation, inotropic and vasopressor support, were adversely related to in-hospital mortality (P < 0.001). On the other hand, presence of initial tachycardia improved short-term outcome (P = 0.007). Long-term survival was worsened by initial atrial fibrillation (P = 0.036) and anaemia (P < 0.001) while the presence of de-novo AHF improved it (P = 0.009). Conclusions Long-term antecedent hypertension is not significantly correlated with mortality after an episode of severe AHF, but probably still participates in vascular and end-organ damage. Survival of these patients is determined by other associated co-morbidities.
ER -
FELŠ$\backslash$H OCI, Marián, Jiří PAŘENICA, Jindřich ŠPINAR, Jiří VÍTOVEC, Petr WIDIMSKÝ, Ales LINHART, Jan VACLAVIK, Filip MÁLEK, Miroslav BAMBUCH, Roman MIKLÍK, Lenka ŠPINAROVÁ, Jan BĚLOHLÁVEK, Čestmír ČIHALÍK and Jiří JARKOVSKÝ. Impact of antecedent hypertension on outcomes in patients hospitalized with severe forms of acute heart failure. \textit{ACTA CARDIOLOGICA}. BRUSSELS: ACTA CARDIOLOGICA, 2012, vol.~67, No~5, p.~515-523. ISSN~0001-5385. doi:10.2143/AC.67.5.2174125.
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