FELŠŐCI, Marián, Jiří PAŘENICA, Jindřich ŠPINAR, Jiří VÍTOVEC, Petr WIDIMSKÝ, Ales LINHART, Jan VACLAVIK, Filip MÁLEK, Miroslav BAMBUCH, Roman MIKLÍK, Lenka ŠPINAROVÁ, Jan BĚLOHLÁVEK, Čestmír ČIHALÍK and Jiří JARKOVSKÝ. Impact of antecedent hypertension on outcomes in patients hospitalized with severe forms of acute heart failure. ACTA CARDIOLOGICA. BRUSSELS: ACTA CARDIOLOGICA, 2012, vol. 67, No 5, p. 515-523. ISSN 0001-5385. doi:10.2143/AC.67.5.2174125.
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Basic information
Original name Impact of antecedent hypertension on outcomes in patients hospitalized with severe forms of acute heart failure
Authors FELŠŐCI, Marián (703 Slovakia, guarantor, belonging to the institution), Jiří PAŘENICA (203 Czech Republic, belonging to the institution), Jindřich ŠPINAR (203 Czech Republic, belonging to the institution), Jiří VÍTOVEC (203 Czech Republic, belonging to the institution), Petr WIDIMSKÝ (203 Czech Republic), Ales LINHART (203 Czech Republic), Jan VACLAVIK (203 Czech Republic), Filip MÁLEK (203 Czech Republic), Miroslav BAMBUCH (203 Czech Republic), Roman MIKLÍK (203 Czech Republic, belonging to the institution), Lenka ŠPINAROVÁ (203 Czech Republic), Jan BĚLOHLÁVEK (203 Czech Republic), Čestmír ČIHALÍK (203 Czech Republic) and Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution).
Edition ACTA CARDIOLOGICA, BRUSSELS, ACTA CARDIOLOGICA, 2012, 0001-5385.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher Belgium
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.607
RIV identification code RIV/00216224:14110/12:00064932
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.2143/AC.67.5.2174125
UT WoS 000310192400002
Keywords in English Hypertension; pulmonary oedema; cardiogenic shock; heart failure; survival
Tags International impact
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 22. 4. 2013 23:54.
Abstract
Objective Even though several studies described a positive influence of elevated initial blood pressure on the outcome in acute heart failure (AHF), data specifically addressed to a population with severe AHF associated with antecedent hypertension, regardless of admission blood pressure values, are missing. Methods and results From the 4153 consecutive patients enrolled in the Czech AHF registry we selected 1343 patients who suffered from pulmonary oedema or cardiogenic shock and compared them according to the presence of antecedent hypertension. Demographic, clinical, laboratory, treatment profiles and mortality rates were assessed and predictors of short- and long-term outcome were identified. Patients with antecedent hypertension (n = 1053, 78%) were older (P < 0.001), more often women (P. 0.001), having more co-morbidities and a worse laboratory profile. A trend for worse survival of hypertensive patients was observed when compared to a non-hypertensive cohort (1-, 2-, 3-year survival 70.0, 61.5, 55.5% vs. 72.6, 68.2, 64.0%, P = 0.062). Age and creatinine levels were independently associated with mortality during the whole follow-up period (P < 0.001). Low left ventricular ejection fraction, need of mechanical ventilation, inotropic and vasopressor support, were adversely related to in-hospital mortality (P < 0.001). On the other hand, presence of initial tachycardia improved short-term outcome (P = 0.007). Long-term survival was worsened by initial atrial fibrillation (P = 0.036) and anaemia (P < 0.001) while the presence of de-novo AHF improved it (P = 0.009). Conclusions Long-term antecedent hypertension is not significantly correlated with mortality after an episode of severe AHF, but probably still participates in vascular and end-organ damage. Survival of these patients is determined by other associated co-morbidities.
Links
MUNI/A/0811/2011, interní kód MUName: Genetické a elektrokardiografické faktory prognózy pacientů se srdečním selháním (Acronym: GESS)
Investor: Masaryk University, Category A
NS9880, research and development projectName: Komplexní managment péče o pacienty as akutním srdečním selháním, jejichstřednědobá prognóza a multivariantní prognostický model
Investor: Ministry of Health of the CR
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