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@proceedings{1079797,
author = {Hradilová Svíženská, Ivana and Klusáková, Ilona and Brázda, Václav and Dubový, Petr},
booktitle = {FENS Forum of Neuroscience Barcelona},
keywords = {CB2; nucleus gracilis; chronic constriction injury; dorsal root ganglia},
title = {Type 2 Cannabinoid Receptor Protein and mRNA Expression in Dorsal Column Nuclei of Two Rat Neuropathic Pain Models},
url = {http://fens.ekonnect.co/FENS_331},
year = {2012}
}
TY - CONF
ID - 1079797
AU - Hradilová Svíženská, Ivana - Klusáková, Ilona - Brázda, Václav - Dubový, Petr
PY - 2012
TI - Type 2 Cannabinoid Receptor Protein and mRNA Expression in Dorsal Column Nuclei of Two Rat Neuropathic Pain Models
KW - CB2
KW - nucleus gracilis
KW - chronic constriction injury
KW - dorsal root ganglia
UR - http://fens.ekonnect.co/FENS_331
N2 - CB2R activation inhibits pain responses without adverse, most often psychotropic effects that are produced by CB1R agonists. The aim of this study was to examine the dorsal column nuclei for CB2R expression following peripheral nerve injury and to explore a possibility of its contribution to neuropathic pain. Using immunohistochemistry and in situ hybridization in two rat neuropathic pain models, sciatic nerve chronic constriction injury (CCI) and spared nerve injury (SNI), we investigated CB2R synthesis and protein distribution in the dorsal column nuclei.Our results demonstrate that expression of CB2 receptors coincides with hyperactivity of medullary microglia what may contribute to the pathogenesis of neuropathic pain.
ER -
HRADILOVÁ SVÍŽENSKÁ, Ivana, Ilona KLUSÁKOVÁ, Václav BRÁZDA and Petr DUBOVÝ. Type 2 Cannabinoid Receptor Protein and mRNA Expression in Dorsal Column Nuclei of Two Rat Neuropathic Pain Models. In \textit{FENS Forum of Neuroscience Barcelona}. 2012.
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