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@article{1079830,
author = {Staršíchová, Andrea and Hrubá, Eva and Slabáková, Eva and Pernicová, Zuzana and Procházková, Jiřina and Pěnčíková, Kateřina and Šeda, Václav and Kabátková, Markéta and Vondráček, Jan and Kozubík, Alois and Machala, Miroslav and Souček, Karel},
article_location = {NEW YORK},
article_number = {8},
doi = {http://dx.doi.org/10.1016/j.cellsig.2012.04.008},
keywords = {Transforming growth factor-beta; Prostate epithelial cells; Aryl hydrocarbon receptor; SMAD4},
language = {eng},
issn = {0898-6568},
journal = {Cellular Signalling},
note = {Opraven obor publikace},
title = {TGF-beta 1 signaling plays a dominant role in the crosstalk between TGF-beta 1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells},
volume = {24},
year = {2012}
}
TY - JOUR
ID - 1079830
AU - Staršíchová, Andrea - Hrubá, Eva - Slabáková, Eva - Pernicová, Zuzana - Procházková, Jiřina - Pěnčíková, Kateřina - Šeda, Václav - Kabátková, Markéta - Vondráček, Jan - Kozubík, Alois - Machala, Miroslav - Souček, Karel
PY - 2012
TI - TGF-beta 1 signaling plays a dominant role in the crosstalk between TGF-beta 1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells
JF - Cellular Signalling
VL - 24
IS - 8
SP - 1665-1676
EP - 1665-1676
PB - ELSEVIER SCIENCE INC
SN - 08986568
N1 - Opraven obor publikace
KW - Transforming growth factor-beta
KW - Prostate epithelial cells
KW - Aryl hydrocarbon receptor
KW - SMAD4
N2 - Crosstalk between the aryl hydrocarbon receptor (AhR) and transforming growth factor-beta 1 (TGF-beta 1) signaling has been observed in various experimental models. However, both molecular mechanism underlying this crosstalk and tissue-specific context of this interaction are still only partially understood. In a model of human non-tumorigenic prostate epithelial cells BPH-1, derived from the benign prostatic hyperplasia, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) persistently activates the AhR signaling pathway and induces expression of xenobiotic metabolizing enzymes, such as CYP1A1 or CYP1B1. Here we demonstrate that TGF-beta 1 suppresses the AhR-mediated gene expression through multiple mechanisms, involving inhibition of AhR expression and down-regulation of nuclear AhR, via a SMAD4-dependent pathway. In contrast, TCDD-induced AhR signaling does not affect either TGF-beta 1-regulated gene expression or epithelial-to-mesenchymal transition. These observations suggest that, in the context of prostate epithelium, TGF-beta 1 signaling plays a dominant role in the crosstalk with AhR signaling pathway. Given the importance of TGF-beta 1 signaling in regulation of prostate epithelial tissue homeostasis, as well as the recently revealed role of AhR in prostate development and tumorigenesis, the above findings contribute to our understanding of the mechanisms underlying the crosstalk between the two signaling pathways in the prostate-specific context. (C) 2012 Elsevier Inc. All rights reserved.
ER -
STARŠÍCHOVÁ, Andrea, Eva HRUBÁ, Eva SLABÁKOVÁ, Zuzana PERNICOVÁ, Jiřina PROCHÁZKOVÁ, Kateřina PĚNČÍKOVÁ, Václav ŠEDA, Markéta KABÁTKOVÁ, Jan VONDRÁČEK, Alois KOZUBÍK, Miroslav MACHALA and Karel SOUČEK. TGF-beta 1 signaling plays a dominant role in the crosstalk between TGF-beta 1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells. \textit{Cellular Signalling}. NEW YORK: ELSEVIER SCIENCE INC, 2012, vol.~24, No~8, p.~1665-1676. ISSN~0898-6568. Available from: https://dx.doi.org/10.1016/j.cellsig.2012.04.008.
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