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@article{1079898,
author = {Poprach, Alexandr and Pavlík, Tomáš and Melichar, Bohuslav and Puzanov, Igor and Dušek, Ladislav and Bortlíček, Zbyněk and Vyzula, Rostislav and Abrahámová, Jitka and Büchler, Tomáš},
article_number = {12},
doi = {http://dx.doi.org/10.1093/annonc/mds145},
keywords = {hand–foot syndrome; rash; renal cell cancer; sorafenib; sunitinib; survival},
language = {eng},
issn = {0923-7534},
journal = {Annals of Oncology},
title = {Skin toxicity and efficacy of sunitinib and sorafenib in metastatic renal cell carcinoma: a national registry-based study},
url = {http://annonc.oxfordjournals.org/content/early/2012/06/13/annonc.mds145.abstract},
volume = {23},
year = {2012}
}
TY - JOUR
ID - 1079898
AU - Poprach, Alexandr - Pavlík, Tomáš - Melichar, Bohuslav - Puzanov, Igor - Dušek, Ladislav - Bortlíček, Zbyněk - Vyzula, Rostislav - Abrahámová, Jitka - Büchler, Tomáš
PY - 2012
TI - Skin toxicity and efficacy of sunitinib and sorafenib in metastatic renal cell carcinoma: a national registry-based study
JF - Annals of Oncology
VL - 23
IS - 12
SP - 3137-3143
EP - 3137-3143
SN - 09237534
KW - hand–foot syndrome
KW - rash
KW - renal cell cancer
KW - sorafenib
KW - sunitinib
KW - survival
UR - http://annonc.oxfordjournals.org/content/early/2012/06/13/annonc.mds145.abstract
L2 - http://annonc.oxfordjournals.org/content/early/2012/06/13/annonc.mds145.abstract
N2 - Background: A retrospective, registry-based analysis to assess the outcomes of metastatic renal cell cancer (mRCC) patients treated with sunitinib and sorafenib who developed dermatologic adverse events was performed. Patients and Methods: Data on mRCC patients treated with sunitinib or sorafenib were obtained from the Czech Clinical Registry of Renal Cell Cancer Patients. Outcomes of patients who developed hand–foot syndrome (HFS) of any grade and/or grade 3/4 rash during the treatment were compared with patients without HFS and no, mild, or moderate rash. Results: The cohort included 705 patients treated with sunitinib and 365 patients treated with sorafenib. For sunitinib, the median overall survival (OS) was 43.0 months versus 31.0 months (P = 0.027) and median progression-free survival (PFS) 20.8 months versus 11.1 months (P = 0.007) for patients with versus without dermatologic toxicity, respectively. For sorafenib, the median OS and PFS were 27.9 and 24.6 months (P = 0.244), and 12.2 and 8.8 months (P = 0.050), respectively. In multivariable Cox regression, the skin toxicity was significantly associated with longer OS in the sunitinib cohort. Conclusion: The presence of skin toxicity is associated with improved OS and PFS in patients with mRCC treated with sunitinib.
ER -
POPRACH, Alexandr, Tomáš PAVLÍK, Bohuslav MELICHAR, Igor PUZANOV, Ladislav DUŠEK, Zbyněk BORTLÍČEK, Rostislav VYZULA, Jitka ABRAHÁMOVÁ a Tomáš BÜCHLER. Skin toxicity and efficacy of sunitinib and sorafenib in metastatic renal cell carcinoma: a national registry-based study. \textit{Annals of Oncology}. roč.~23, č.~12, s.~3137-3143. ISSN~0923-7534. doi:10.1093/annonc/mds145. 2012.
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