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@article{1080443,
author = {Verner, Jan and Kabáthová, Jitka and Tomancová, Alexandra and Pavlová, Šárka and Tichý, Boris and Mráz, Marek and Brychtová, Yvona and Krejčí, Marta and Zdráhal, Zbyněk and Trbušek, Martin and Volejníková, Jana and Sedláček, Petr and Doubek, Michael and Mayer, Jiří and Pospíšilová, Šárka},
article_location = {New York},
article_number = {11},
doi = {http://dx.doi.org/10.1016/j.exphem.2012.06.011},
keywords = {MONONUCLEAR-CELLS; ACUTE GVHD; BLOOD; MICROARRAYS; BIOMARKERS; THERAPY},
language = {eng},
issn = {0301-472X},
journal = {Experimental Hematology},
title = {Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22771791},
volume = {40},
year = {2012}
}
TY - JOUR
ID - 1080443
AU - Verner, Jan - Kabáthová, Jitka - Tomancová, Alexandra - Pavlová, Šárka - Tichý, Boris - Mráz, Marek - Brychtová, Yvona - Krejčí, Marta - Zdráhal, Zbyněk - Trbušek, Martin - Volejníková, Jana - Sedláček, Petr - Doubek, Michael - Mayer, Jiří - Pospíšilová, Šárka
PY - 2012
TI - Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation
JF - Experimental Hematology
VL - 40
IS - 11
SP - 899-905
EP - 899-905
PB - Elsevier Science
SN - 0301472X
KW - MONONUCLEAR-CELLS
KW - ACUTE GVHD
KW - BLOOD
KW - MICROARRAYS
KW - BIOMARKERS
KW - THERAPY
UR - http://www.ncbi.nlm.nih.gov/pubmed/22771791
L2 - http://www.ncbi.nlm.nih.gov/pubmed/22771791
N2 - Acute graft-vs-host disease (aGVHD) is a frequent, life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Despite that, there are no reliable molecular markers reflecting the onset or clinical course of aGVHD. We performed a pilot study on gene expression profiling in peripheral blood mononuclear cells taken from 15 patients with hematological malignancies who underwent allo-HSCT and developed aGVHD. Based on survival rates after aGVHD, patients were divided into two groups-favorable (all patients alive; median follow-up 40 months) vs unfavorable group (all patients died; median survival 2 months). Two-hundred and eighty genes differentially expressed between these two groups were identified; among them, genes responsible for cytokine signaling, inflammatory response, and regulation of cell cycle were over-represented; interleukin-8, GOS2, ANXA3, and NR4A2 were upregulated in the unfavorable group, CDKN1C was downregulated in the same group. Interestingly, the same genes were also described as overexpressed in connection with autoimmune diseases. This indicates an involvement of similar immune regulatory pathways also in aGVHD. Our data support use of gene expression profiling at aGVHD onset for a prediction of its outcomes. (C) 2012 ISEH - Society for Hematology and Stem Cells.
ER -
VERNER, Jan, Jitka KABÁTHOVÁ, Alexandra TOMANCOVÁ, Šárka PAVLOVÁ, Boris TICHÝ, Marek MRÁZ, Yvona BRYCHTOVÁ, Marta KREJČÍ, Zbyněk ZDRÁHAL, Martin TRBUŠEK, Jana VOLEJNÍKOVÁ, Petr SEDLÁČEK, Michael DOUBEK, Jiří MAYER and Šárka POSPÍŠILOVÁ. Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation. \textit{Experimental Hematology}. New York: Elsevier Science, 2012, vol.~40, No~11, p.~899-905. ISSN~0301-472X. Available from: https://dx.doi.org/10.1016/j.exphem.2012.06.011.
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