| BENEŠOVÁ, Yvonne, Anna VAŠKŮ, Pavel ŠTOURAČ, Magdaléna HLADÍKOVÁ, Adam FIALA and Josef BEDNAŘÍK. Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis. Journal of Neuroimmunology. Netherlands: Elsevier/North-Holland, 2013, vol. 255, 1-2, p. 92-96. ISSN 0165-5728. doi:10.1016/j.jneuroim.2012.10.014. |
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@article{1080956,
author = {Benešová, Yvonne and Vašků, Anna and Štourač, Pavel and Hladíková, Magdaléna and Fiala, Adam and Bednařík, Josef},
article_location = {Netherlands},
article_number = {1-2},
doi = {http://dx.doi.org/10.1016/j.jneuroim.2012.10.014},
keywords = {Gene; HLA-DRB1*1501; Multiple sclerosis; Tagging polymorphism},
language = {eng},
issn = {0165-5728},
journal = {Journal of Neuroimmunology},
title = {Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis},
url = {http://www.sciencedirect.com/science/article/pii/S0165572812003177},
volume = {255},
year = {2013}
}
TY - JOUR
ID - 1080956
AU - Benešová, Yvonne - Vašků, Anna - Štourač, Pavel - Hladíková, Magdaléna - Fiala, Adam - Bednařík, Josef
PY - 2013
TI - Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis
JF - Journal of Neuroimmunology
VL - 255
IS - 1-2
SP - 92-96
EP - 92-96
PB - Elsevier/North-Holland
SN - 01655728
KW - Gene
KW - HLA-DRB1*1501
KW - Multiple sclerosis
KW - Tagging polymorphism
UR - http://www.sciencedirect.com/science/article/pii/S0165572812003177
L2 - http://www.sciencedirect.com/science/article/pii/S0165572812003177
N2 - We investigated the HLA-DRB1*1501 tagging rs3135388 gene polymorphism and its association with multiple sclerosis (MS) susceptibility, disability and gender differences. The study group consisted of 306 MS patients and 137 healthy individuals. A significant difference in genotype distribution (Pg = 3.06 x 10 - 9) and allele frequency (Pa = 6.08 x 10- 10) between MS patients and controls was demonstrated. The homozygotes AA and heterozygotes GA were more frequent in MS patients (OR = 4.27, 95% CI: 2.64-6.92). A significant difference between female MS patients and female controls in genotype distribution (Pg = 1.3 x 10- 8) and allele frequency (Pa = 2.82 x 10- 9); (OR = 5.11, 95% CI: 2.86-9.15) was also proved. Our results indicate that the distribution of the rs3135388 gene polymorphism is a risk factor for MS susceptibility in the Czech female population.
ER -
BENEŠOVÁ, Yvonne, Anna VAŠKŮ, Pavel ŠTOURAČ, Magdaléna HLADÍKOVÁ, Adam FIALA and Josef BEDNAŘÍK. Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis. \textit{Journal of Neuroimmunology}. Netherlands: Elsevier/North-Holland, 2013, vol.~255, 1-2, p.~92-96. ISSN~0165-5728. doi:10.1016/j.jneuroim.2012.10.014.
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