BENEŠOVÁ, Yvonne, Anna VAŠKŮ, Pavel ŠTOURAČ, Magdaléna HLADÍKOVÁ, Adam FIALA and Josef BEDNAŘÍK. Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis. Journal of Neuroimmunology. Netherlands: Elsevier/North-Holland, 2013, vol. 255, 1-2, p. 92-96. ISSN 0165-5728. doi:10.1016/j.jneuroim.2012.10.014.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis
Authors BENEŠOVÁ, Yvonne (203 Czech Republic, guarantor, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, belonging to the institution), Pavel ŠTOURAČ (203 Czech Republic, belonging to the institution), Magdaléna HLADÍKOVÁ (203 Czech Republic), Adam FIALA (203 Czech Republic, belonging to the institution) and Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution).
Edition Journal of Neuroimmunology, Netherlands, Elsevier/North-Holland, 2013, 0165-5728.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.786
RIV identification code RIV/00216224:14110/13:00067608
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.jneuroim.2012.10.014
UT WoS 000315014700013
Keywords in English Gene; HLA-DRB1*1501; Multiple sclerosis; Tagging polymorphism
Tags podil
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 24. 1. 2014 19:26.
Abstract
We investigated the HLA-DRB1*1501 tagging rs3135388 gene polymorphism and its association with multiple sclerosis (MS) susceptibility, disability and gender differences. The study group consisted of 306 MS patients and 137 healthy individuals. A significant difference in genotype distribution (Pg = 3.06 x 10 - 9) and allele frequency (Pa = 6.08 x 10- 10) between MS patients and controls was demonstrated. The homozygotes AA and heterozygotes GA were more frequent in MS patients (OR = 4.27, 95% CI: 2.64-6.92). A significant difference between female MS patients and female controls in genotype distribution (Pg = 1.3 x 10- 8) and allele frequency (Pa = 2.82 x 10- 9); (OR = 5.11, 95% CI: 2.86-9.15) was also proved. Our results indicate that the distribution of the rs3135388 gene polymorphism is a risk factor for MS susceptibility in the Czech female population.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
PrintDisplayed: 8. 8. 2022 15:43