a 2012

Cell motility in marine early emerging apicomplexans

VALIGUROVÁ, Andrea, Andrei DIAKIN, Timur G. SIMDYANOV and Joseph SCHREVEL

Basic information

Original name

Cell motility in marine early emerging apicomplexans

Name in Czech

Cell motility in marine early emerging apicomplexans

Authors

VALIGUROVÁ, Andrea (703 Slovakia, guarantor, belonging to the institution), Andrei DIAKIN (643 Russian Federation), Timur G. SIMDYANOV (643 Russian Federation) and Joseph SCHREVEL (250 France)

Edition

Workshop ECIP 2012, Šatov, 2012

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

10600 1.6 Biological sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/12:00058218

Organization unit

Faculty of Science

Keywords (in Czech)

apicomplexa; gregarines; cell motility; cortex; pellicle; actin; myosin; marine

Keywords in English

apicomplexa; gregarines; cell motility; cortex; pellicle; actin; myosin; marine

Abstract

ORIG CZ

V originále

Apicomplexans represent one of the most successful and diverse group of unicellular parasites exhibiting unique adaptations to their life style. Many of them are causative agents for major human diseases (such as malaria, toxoplasmosis and cryptosporidiosis), which are still poorly controlled and require development of novel sustainable therapies. The apicomplexan cytoskeletal elements play an important role in various life processes and thus they represent a potential target for chemotherapeutic intervention. Their highly motile invasive zoites use a unique conserved form of actin-based gliding motility for movement, host cell invasion and tissue traversal. Our intent is to investigate if the glideosome concept, proposed in Toxoplasma, could be also applied to basal lineages of Apicomplexa. We focus on deep-branching groups, especially gregarines and protococcidians, restricted to invertebrates (Diakin et al. 2012). They are important from an evolutionary perspective because of their basal position and recent analyses pointing out close affinity of gregarines with Cryptosporidium (Valigurová et al. 2007, 2008). Improved knowledge about their motility, including gliding, pendular or rolling and metabolic movements, as well as invasion strategies (Valigurová et al. 2009, Valigurová 2012) would offer significant insights into the biology and evolutionary strategies of Apicomplexa. The motility mechanisms need further investigations to integrate the structural information along with biochemical and molecular analyses.

In Czech

Apicomplexans represent one of the most successful and diverse group of unicellular parasites exhibiting unique adaptations to their life style. Many of them are causative agents for major human diseases (such as malaria, toxoplasmosis and cryptosporidiosis), which are still poorly controlled and require development of novel sustainable therapies. The apicomplexan cytoskeletal elements play an important role in various life processes and thus they represent a potential target for chemotherapeutic intervention. Their highly motile invasive zoites use a unique conserved form of actin-based gliding motility for movement, host cell invasion and tissue traversal. Our intent is to investigate if the glideosome concept, proposed in Toxoplasma, could be also applied to basal lineages of Apicomplexa. We focus on deep-branching groups, especially gregarines and protococcidians, restricted to invertebrates (Diakin et al. 2012). They are important from an evolutionary perspective because of their basal position and recent analyses pointing out close affinity of gregarines with Cryptosporidium (Valigurová et al. 2007, 2008). Improved knowledge about their motility, including gliding, pendular or rolling and metabolic movements, as well as invasion strategies (Valigurová et al. 2009, Valigurová 2012) would offer significant insights into the biology and evolutionary strategies of Apicomplexa. The motility mechanisms need further investigations to integrate the structural information along with biochemical and molecular analyses.

Links

GBP505/12/G112, research and development project
Name: ECIP - Evropské centrum ichtyoparazitologie
Investor: Czech Science Foundation