Circulating Levels of B-cell Activating Factor in Paediatric
Patients with Malignancy With or without Cancer-Related
Cachexia

J 2012

Circulating Levels of B-cell Activating Factor in Paediatric Patients with Malignancy With or without Cancer-Related Cachexia

BIENERTOVÁ VAŠKŮ, Julie, Alena LUNGOVÁ, Petr BIENERT, Filip ZLÁMAL, Josef TOMANDL et. al.

Basic information

Original name

Circulating Levels of B-cell Activating Factor in Paediatric Patients with Malignancy With or without Cancer-Related Cachexia

Authors

BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor, belonging to the institution), Alena LUNGOVÁ (203 Czech Republic), Petr BIENERT (203 Czech Republic, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Marie TOMANDLOVÁ (203 Czech Republic, belonging to the institution), Zbyněk ŠPLÍCHAL (203 Czech Republic, belonging to the institution) and Jaroslav ŠTĚRBA (203 Czech Republic)

Edition

Klinická onkologie, Praha, Ambit Media a.s. 2012, 0862-495X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/12:00063158

Organization unit

Faculty of Medicine

Keywords (in Czech)

faktor aktivující B buňky (BAFF); nádorová kachexie; nádorové onemocnění; pediatrická onkologie

Keywords in English

B cell-activating factor; cachexia; cancer; paediatrics

Abstract

V originále

Cancer-related cachexia is a multifactorial syndrome characterised by progressive loss of body weight and it affects a large proportion of patients with advanced cancer. Cachexia is associated with reduced treatment tolerance, response to therapy, quality of life and duration of survival, whereas some of its mechanisms are shared across the whole continuum of diseases in the population, either cancer-related or non-cancer related e.g. systemic inflammation, increased lipolysis, insulin resistance and reduced physical performance. However, so far there has been only little effort to utilise the integrative physiology of adipose tissue to achieve therapeutic gain. B cell-activating factor (BAFF) is a novel member of the TNF ligand superfamily, is mainly produced by myeloid cells and has recently been shown to participate in B-cell survival and B- and T-cell maturation, but also in adipogenesis. Therefore, it represents an elegant candidate molecule linking the immune system and adipose tissue metabolism, both being involved deeply in the pathogenesis of cachexia. Moreover, it has been described very recently that BAFF directly influences secretion of IL-6 and IL-10.

Files attached

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Citovat

BIENERTOVÁ VAŠKŮ, Julie, Alena LUNGOVÁ, Petr BIENERT, Filip ZLÁMAL, Josef TOMANDL, Marie TOMANDLOVÁ, Zbyněk ŠPLÍCHAL and Jaroslav ŠTĚRBA. Circulating Levels of B-cell Activating Factor in Paediatric Patients with Malignancy With or without Cancer-Related Cachexia. Klinická onkologie. Praha: Ambit Media a.s., 2012, vol. 25, Supplement 2, p. 58– 63. ISSN 0862-495X.

@article{1083893,
   author = {Bienertová Vašků, Julie and Lungová, Alena and Bienert, Petr and Zlámal, Filip and Tomandl, Josef and Tomandlová, Marie and Šplíchal, Zbyněk and Štěrba, Jaroslav},
   article_location = {Praha},
   article_number = {Supplement 2},
   keywords = {B cell-activating factor; cachexia; cancer; paediatrics},
   language = {eng},
   issn = {0862-495X},
   journal = {Klinická onkologie},
   title = {Circulating Levels of B-cell Activating Factor in Paediatric Patients with Malignancy With or without Cancer-Related Cachexia},
   volume = {25},
   year = {2012}
}

TY  - JOUR
ID  - 1083893
AU  - Bienertová Vašků, Julie - Lungová, Alena - Bienert, Petr - Zlámal, Filip - Tomandl, Josef - Tomandlová, Marie - Šplíchal, Zbyněk - Štěrba, Jaroslav
PY  - 2012
TI  - Circulating Levels of B-cell Activating Factor in Paediatric Patients with Malignancy With or without Cancer-Related Cachexia
JF  - Klinická onkologie
VL  - 25
IS  - Supplement 2
SP  - 58– 63
EP  - 58– 63
PB  - Ambit Media a.s.
SN  - 0862495X
KW  - B cell-activating factor
KW  - cachexia
KW  - cancer
KW  - paediatrics
N2  - Cancer-related cachexia is a multifactorial syndrome characterised by progressive loss of body weight and it affects a large proportion of patients with advanced cancer. Cachexia is associated with reduced treatment tolerance, response to therapy, quality of life and duration of survival, whereas some of its mechanisms are shared across the whole continuum of diseases in the population, either cancer-related or non-cancer related e.g. systemic inflammation, increased lipolysis, insulin resistance and reduced physical performance. However, so far there has been only little effort to utilise the integrative physiology of adipose tissue to achieve therapeutic gain. B cell-activating factor (BAFF) is a novel member of the TNF ligand superfamily, is mainly produced by myeloid cells and has recently been shown to participate in B-cell survival and B- and T-cell maturation, but also in adipogenesis. Therefore, it represents an elegant candidate molecule linking the immune system and adipose tissue metabolism, both being involved deeply in the pathogenesis of cachexia. Moreover, it has been described very recently that BAFF directly influences secretion of IL-6 and IL-10.
ER  -

BIENERTOVÁ VAŠKŮ, Julie, Alena LUNGOVÁ, Petr BIENERT, Filip ZLÁMAL, Josef TOMANDL, Marie TOMANDLOVÁ, Zbyněk ŠPLÍCHAL and Jaroslav ŠTĚRBA. Circulating Levels of B-cell Activating Factor in Paediatric Patients with Malignancy With or without Cancer-Related Cachexia. \textit{Klinická onkologie}. Praha: Ambit Media a.s., 2012, vol.~25, Supplement 2, p.~58– 63. ISSN~0862-495X.

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