BULIK, Martin, Radim JANČÁLEK, Jiří VANÍČEK, Antonín ŠKOCH and Marek MECHL. Potential of MR spectroscopy for assessment of glioma grading. Clinical Neurology and Neurosurgery. Amsterdam: Elsevier, 2013, vol. 115, No 2, p. 146-153. ISSN 0303-8467. Available from: https://dx.doi.org/10.1016/j.clineuro.2012.11.002.
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Basic information
Original name Potential of MR spectroscopy for assessment of glioma grading
Authors BULIK, Martin (203 Czech Republic, guarantor, belonging to the institution), Radim JANČÁLEK (203 Czech Republic, belonging to the institution), Jiří VANÍČEK (203 Czech Republic, belonging to the institution), Antonín ŠKOCH (203 Czech Republic) and Marek MECHL (203 Czech Republic, belonging to the institution).
Edition Clinical Neurology and Neurosurgery, Amsterdam, Elsevier, 2013, 0303-8467.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.248
RIV identification code RIV/00216224:14110/13:00067698
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.clineuro.2012.11.002
UT WoS 000314447500005
Keywords in English Magnetic resonance spectroscopy; Metabolites; Glioma; Grade
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 4/3/2014 17:19.
Abstract
Magnetic resonance spectroscopy (MRS) is an imaging diagnostic method based that allows non-invasive measurement of metabolites in tissues. There are a number of metabolites that can be identified by standard brain proton MRS but only a few of them has a clinical significance in diagnosis of gliomas including N-acetylaspartate, choline, creatine, myo-inositol, lactate, and lipids. Results: Low-grade gliomas are generally characterized by a relatively high concentration of Nacetylaspartate, low level of choline and absence of lactate and lipids. The increase in creatine concentration indicates low-grade gliomas with earlier progression and malignant transformation. Progression in grade of a glioma is reflected in the progressive decrease in the N-acetylaspartate and myo-inositol levels on the one hand and elevation in choline level up to grade III on the other. Malignant transformation of the glial tumors is also accompanied by the presence of lactate and lipids in MR spectra of grade III but mainly grade IV gliomas. It follows that MRS is a helpful method for detection of glioma regions with aggressive growth or upgrading due to favorable correlation of the choline and N-acetylaspartate levels with histopathological proliferation index Ki-67. Thus, magnetic resonance spectroscopy is also a suitable method for the targeting of brain biopsies. Conclusions: Gliomas of each grade have some specific MRS features that can be used for improvement of the diagnostic value of conventional magnetic resonance imaging in non-invasive assessment of glioma grade.
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