ŽOURKOVÁ, Alexandra, Ondřej SLANAŘ, Jiří JARKOVSKÝ, Ivana PALČÍKOVÁ, Eva PINDUROVÁ and Michaela CVANOVÁ. MDR1 in Paroxetine-Induced Sexual Dysfunction. Journal of Sex and Marital Therapy. USA: Taylor and Francis Health Sciences, 2013, vol. 39, No 1, p. 71-78. ISSN 0092-623X. Available from: https://dx.doi.org/10.1080/0092623X.2012.668514.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name MDR1 in Paroxetine-Induced Sexual Dysfunction
Authors ŽOURKOVÁ, Alexandra (203 Czech Republic, guarantor, belonging to the institution), Ondřej SLANAŘ (203 Czech Republic), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Ivana PALČÍKOVÁ (203 Czech Republic, belonging to the institution), Eva PINDUROVÁ (203 Czech Republic, belonging to the institution) and Michaela CVANOVÁ (203 Czech Republic, belonging to the institution).
Edition Journal of Sex and Marital Therapy, USA, Taylor and Francis Health Sciences, 2013, 0092-623X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.667
RIV identification code RIV/00216224:14110/13:00067710
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1080/0092623X.2012.668514
UT WoS 000311238400006
Keywords in English P-GLYCOPROTEIN; MDR1; Sexual Dysfunction
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 7/2/2013 08:34.
Abstract
Paroxetine-induced sexual dysfunction represents a frequent treatment complication of otherwise efficient antidepressants. The genetic polymorphism of pharmacokinetic genes may contribute to the occurrence of such dysfunctions. This study presents the effect of MDR1 gene polymorphisms on sexual function in 18 women with bulimia nervosa, 18 women with anxiety disorders, and 19 healthy control subjects. It also deals with the relation between MDR1 gene polymorphisms and paroxetine-induced sexual dysfunction. The results demonstrated that MDR1 G2677T/A gene polymorphism allele carriers treated with paroxetine presented with difficulties with orgasm (p = .008) and lubrication (p < .001).
PrintDisplayed: 24/8/2024 19:37