HANINEC, Pavel, Radek KAISER and Petr DUBOVÝ. A Comparison of Collateral Sprouting of Sensory and Motor Axons after End-to-Side Neurorrhaphy with and without the Perineurial Window. PLASTIC AND RECONSTRUCTIVE SURGERY. Philadelphia: Lippincott Williams & Wilkins, 2012, vol. 130, No 3, p. 609-614. ISSN 0032-1052. doi:10.1097/PRS.0b013e31825dc20a.
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Basic information
Original name A Comparison of Collateral Sprouting of Sensory and Motor Axons after End-to-Side Neurorrhaphy with and without the Perineurial Window
Authors HANINEC, Pavel (203 Czech Republic), Radek KAISER (203 Czech Republic) and Petr DUBOVÝ (203 Czech Republic, guarantor, belonging to the institution).
Edition PLASTIC AND RECONSTRUCTIVE SURGERY, Philadelphia, Lippincott Williams & Wilkins, 2012, 0032-1052.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.535
RIV identification code RIV/00216224:14110/12:00063475
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1097/PRS.0b013e31825dc20a
UT WoS 000308458300049
Keywords in English PERIPHERAL-NERVE REPAIR; LONG-TERM EVALUATION; RAT BRACHIAL-PLEXUS; TERMINOLATERAL NEURORRHAPHY; MUSCULOCUTANEOUS NERVE; EXPERIMENTAL-MODEL; REGENERATION; INJURY; ANASTOMOSIS; RECOVERY
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 25. 2. 2013 10:52.
Abstract
Background: Many experimental studies have confirmed collateral sprouting of axons after end-to-side neurorrhaphy and its possible clinical application. There is still controversy about how the surgical method should be carried out. The aim of the present study was to quantitatively evaluate collateral sprouting of motor and sensory axons after end-to-side neurorrhaphy with and without the perineurial window. Methods: End-to-side neurorrhaphy of the distal stump of transected musculocutaneous nerve with intact ulnar nerve with or without a perineurial window was performed in a rat model. Collateral sprouts were quantitatively evaluated by counting of motor and sensory neurons following their retrograde labeling by Fluoro-Ruby and Fluoro-Emerald applied to the ulnar and musculocutaneous nerves, respectively. Results: Our results show that significantly more motor and sensory axons sent their collateral branches into the recipient nerve in the group with a perineurial window. Some axons were injured during preparation of the perineurial window; the injured axons reinnervated directly into the recipient nerve to contribute to results of functional reinnervation. Conclusion: The authors conclude that it is necessary to create a perineurial window when using end-to-side neurorrhaphy in clinical practice, especially in brachial plexus reconstruction. (Plast. Reconstr. Surg. 130: 609, 2012.)
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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