| ČERNÁ, Marie, M. ČEJKOVÁ, Petronela AMBROŠOVÁ, Pavel KUKLÍNEK, Hana MELUZÍNOVÁ, Vlasta POLCAROVÁ and Pavel WEBER. HLA alleles in autoimmune diabetes mellitus with onset after 35 year. In VII European Congress of IAGG, „Healthy and Active Ageing for All Europeanss". 2011. ISSN 1594-0667. |
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@proceedings{1085404,
author = {Černá, Marie and Čejková, M. and Ambrošová, Petronela and Kuklínek, Pavel and Meluzínová, Hana and Polcarová, Vlasta and Weber, Pavel},
booktitle = {VII European Congress of IAGG, „Healthy and Active Ageing for All Europeanss"},
keywords = {LADA - HLA system - appearence after 35 y.},
language = {eng},
title = {HLA alleles in autoimmune diabetes mellitus with onset after 35 year},
year = {2011}
}
TY - CONF
ID - 1085404
AU - Černá, Marie - Čejková, M. - Ambrošová, Petronela - Kuklínek, Pavel - Meluzínová, Hana - Polcarová, Vlasta - Weber, Pavel
PY - 2011
TI - HLA alleles in autoimmune diabetes mellitus with onset after 35 year
KW - LADA - HLA system - appearence after 35 y.
N2 - We summarize that in the Central Bohemian population of the Czech Republic, the INS –23HphI A allele appears to be associated with a decrease in pancreatic beta cell secretory activity. HLA genotyping points to at least a partial difference in mechanism, which leads to T1DM and LADA development as well as a more diverse genetic predisposition in juvenile- and adult-onset diabetes. The simultaneous effect of HLA and INS-VNTR alleles/ genotypes predispose individuals to an increased risk of diabetes development.
ER -
ČERNÁ, Marie, M. ČEJKOVÁ, Petronela AMBROŠOVÁ, Pavel KUKLÍNEK, Hana MELUZÍNOVÁ, Vlasta POLCAROVÁ and Pavel WEBER. HLA alleles in autoimmune diabetes mellitus with onset after 35 year. In \textit{VII European Congress of IAGG, „Healthy and Active Ageing for All Europeanss''}. 2011. ISSN~1594-0667.
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