HLA alleles in autoimmune diabetes mellitus with onset after 35 year

ČERNÁ, Marie, M. ČEJKOVÁ, Petronela AMBROŠOVÁ, Pavel KUKLÍNEK, Hana MELUZÍNOVÁ, Vlasta POLCAROVÁ and Pavel WEBER. HLA alleles in autoimmune diabetes mellitus with onset after 35 year. In VII European Congress of IAGG, „Healthy and Active Ageing for All Europeanss". 2011. ISSN 1594-0667.

Basic information

Original name

HLA alleles in autoimmune diabetes mellitus with onset after 35 year

Name in Czech

HLA alely u autoimunního diabetu se vznikem po 35. roce

Authors

ČERNÁ, Marie (203 Czech Republic, guarantor), M. ČEJKOVÁ (203 Czech Republic), Petronela AMBROŠOVÁ (703 Slovakia, belonging to the institution), Pavel KUKLÍNEK (203 Czech Republic), Hana MELUZÍNOVÁ (203 Czech Republic), Vlasta POLCAROVÁ (203 Czech Republic) and Pavel WEBER (203 Czech Republic)

Edition

VII European Congress of IAGG, „Healthy and Active Ageing for All Europeanss" 2011

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Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Italy

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.552

RIV identification code

RIV/00216224:14110/11:00063510

Organization unit

Faculty of Medicine

ISSN

Keywords (in Czech)

LADA - HLA systém - vznik po 35. roce

Keywords in English

LADA - HLA system - appearence after 35 y.

Tags

International impact, Reviewed

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Abstract

V originále

We summarize that in the Central Bohemian population of the Czech Republic, the INS –23HphI A allele appears to be associated with a decrease in pancreatic beta cell secretory activity. HLA genotyping points to at least a partial difference in mechanism, which leads to T1DM and LADA development as well as a more diverse genetic predisposition in juvenile- and adult-onset diabetes. The simultaneous effect of HLA and INS-VNTR alleles/ genotypes predispose individuals to an increased risk of diabetes development.

In Czech

viz anglický text