| KAŠPÁREK, Tomáš, Radovan PŘIKRYL, Jitka HÜTTLOVÁ, Radek MAREČEK, Michal MIKL, Hana PŘIKRYLOVÁ KUČEROVÁ, Jiří VANÍČEK and Eva ČEŠKOVÁ. Brain Functional Connectivity of Male Patients in Remission After the First Episode of Schizophrenia. Human Brain Mapping. USA: Wiley Periodicals, Inc., 2013, vol. 34, No 3, p. 726-737. ISSN 1065-9471. Available from: https://dx.doi.org/10.1002/hbm.21469. |
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@article{1085788,
author = {Kašpárek, Tomáš and Přikryl, Radovan and Hüttlová, Jitka and Mareček, Radek and Mikl, Michal and Přikrylová Kučerová, Hana and Vaníček, Jiří and Češková, Eva},
article_location = {USA},
article_number = {3},
doi = {http://dx.doi.org/10.1002/hbm.21469},
keywords = {disconnection; remission; schizophrenia},
language = {eng},
issn = {1065-9471},
journal = {Human Brain Mapping},
title = {Brain Functional Connectivity of Male Patients in Remission After the First Episode of Schizophrenia},
volume = {34},
year = {2013}
}
TY - JOUR
ID - 1085788
AU - Kašpárek, Tomáš - Přikryl, Radovan - Hüttlová, Jitka - Mareček, Radek - Mikl, Michal - Přikrylová Kučerová, Hana - Vaníček, Jiří - Češková, Eva
PY - 2013
TI - Brain Functional Connectivity of Male Patients in Remission After the First Episode of Schizophrenia
JF - Human Brain Mapping
VL - 34
IS - 3
SP - 726-737
EP - 726-737
PB - Wiley Periodicals, Inc.
SN - 10659471
KW - disconnection
KW - remission
KW - schizophrenia
N2 - Abnormal task related activation and connectivity is present in schizophrenia. The aim of this study was the analysis of functional networks in schizophrenia patients in remission after the first episode. Experimental design: Twenty nine male patients in remission after the first episode of schizophrenia and 22 healthy controls underwent examination by functional magnetic resonance during verbal fluency tasks (VFT). The functional connectivity of brain networks was analyzed using independent component analysis. Results: The patients showed lower activation of the salience network during VFT. They also showed lower deactivation of the default mode network (DMN) during VFT processing. Spectral analysis of the component time courses showed decreased power in slow frequencies of signal fluctuations in the salience and DMNs and increased power in higher frequencies in the left frontoparietal cortex reflecting higher fluctuations of the network activity. Moreover, there was decreased similarity of component time courses in schizophrenia the patients had smaller negative correlation between VFT activated and deactivated networks, and smaller positive correlations between DMN subcomponents. Conclusions: There is still an abnormal functional connectivity of several brain networks in remission after the first episode of schizophrenia. The effect of different treatment modalities on brain connectivity, together with temporal dynamics of this functional abnormality should be the objective of further studies to assess its potential as a marker of disease stabilization.
ER -
KAŠPÁREK, Tomáš, Radovan PŘIKRYL, Jitka HÜTTLOVÁ, Radek MAREČEK, Michal MIKL, Hana PŘIKRYLOVÁ KUČEROVÁ, Jiří VANÍČEK and Eva ČEŠKOVÁ. Brain Functional Connectivity of Male Patients in Remission After the First Episode of Schizophrenia. \textit{Human Brain Mapping}. USA: Wiley Periodicals, Inc., 2013, vol.~34, No~3, p.~726-737. ISSN~1065-9471. Available from: https://dx.doi.org/10.1002/hbm.21469.
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