Multidrug resistance-associated ABC transporters – too much of
one thing, good for nothing

J 2012

Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing

PROCHÁZKOVÁ, Jiřina, Martina LÁNOVÁ and Jiří PACHERNÍK

Basic information

Original name

Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing

Authors

PROCHÁZKOVÁ, Jiřina (203 Czech Republic, guarantor, belonging to the institution), Martina LÁNOVÁ (203 Czech Republic, belonging to the institution) and Jiří PACHERNÍK (203 Czech Republic, belonging to the institution)

Edition

Biomolecular concepts, 2012, 1868-5021

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14310/12:00063603

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1515/bmc-2012-0006

Keywords in English

ABC transporters; evolution; site mutations

Abstract

V originále

Overexpression of ATP-binding cassette (ABC) transporters in cancer cells results in multidrug resistance (MDR) which leads to unsuccessful chemotherapy. The most important MDR-associated members of ABC superfamily are ABC B1/P-glycoprotein/MDR1, ABC C1/multidrug resistance associated protein 1 (MRP1), and ABC G2/BCRP. This study is not only focused on function, substrates, and localization of these popular proteins but also on other ABC C family members such as ABC C2–6/MRP2-6 and ABC C7/CFTR. Current research is mainly oriented on the cancer-promoting role of these proteins, but important lessons could also be learned from the physiological roles of these proteins or from polymorphisms affecting their function. Thorough knowledge of structure and detailed mechanism of efflux can aid in the discovery of new chemotherapy targets in the future. Although the best way on how to deal with MDR would be to prevent its development, we describe some new promising strategies on how to conquer both inherited and induced MDRs.

Links

MUNI/A/0975/2009, interní kód MU

Name: Podpora výzkumné činnosti studentů v oblasti fyziologie a imunologie živočichů. (Acronym: VYFIŽ)

Investor: Masaryk University, Category A

Citovat

PROCHÁZKOVÁ, Jiřina, Martina LÁNOVÁ and Jiří PACHERNÍK. Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing. Biomolecular concepts. 2012, vol. 3, No 4, p. 319-331. ISSN 1868-5021. Available from: https://dx.doi.org/10.1515/bmc-2012-0006.

@article{1085860,
   author = {Procházková, Jiřina and Lánová, Martina and Pacherník, Jiří},
   article_number = {4},
   doi = {http://dx.doi.org/10.1515/bmc-2012-0006},
   keywords = {ABC transporters; evolution; site mutations},
   language = {eng},
   issn = {1868-5021},
   journal = {Biomolecular concepts},
   title = {Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing},
   url = {http://www.degruyter.com/view/j/bmc},
   volume = {3},
   year = {2012}
}

TY  - JOUR
ID  - 1085860
AU  - Procházková, Jiřina - Lánová, Martina - Pacherník, Jiří
PY  - 2012
TI  - Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing
JF  - Biomolecular concepts
VL  - 3
IS  - 4
SP  - 319-331
EP  - 319-331
SN  - 18685021
KW  - ABC transporters
KW  - evolution
KW  - site mutations
UR  - http://www.degruyter.com/view/j/bmc
L2  - http://www.degruyter.com/view/j/bmc
N2  - Overexpression of ATP-binding cassette (ABC) transporters in cancer cells results in multidrug resistance (MDR) which leads to unsuccessful chemotherapy. The most important MDR-associated members of ABC superfamily are ABC B1/P-glycoprotein/MDR1, ABC C1/multidrug resistance associated protein 1 (MRP1), and ABC G2/BCRP. This study is not only focused on function, substrates, and localization of these popular proteins but also on other ABC C family members such as ABC C2–6/MRP2-6 and ABC C7/CFTR. Current research is mainly oriented on the cancer-promoting role of these proteins, but important lessons could also be learned from the physiological roles of these proteins or from polymorphisms affecting their function. Thorough knowledge of structure and detailed mechanism of efflux can aid in the discovery of new chemotherapy targets in the future. Although the best way on how to deal with MDR would be to prevent its development, we describe some new promising strategies on how to conquer both inherited and induced MDRs.
ER  -

PROCHÁZKOVÁ, Jiřina, Martina LÁNOVÁ and Jiří PACHERNÍK. Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing. \textit{Biomolecular concepts}. 2012, vol.~3, No~4, p.~319-331. ISSN~1868-5021. Available from: https://dx.doi.org/10.1515/bmc-2012-0006.

Detailed Information on Publication Record