Detailed Information on Publication Record
2012
Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing
PROCHÁZKOVÁ, Jiřina, Martina LÁNOVÁ and Jiří PACHERNÍKBasic information
Original name
Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing
Authors
PROCHÁZKOVÁ, Jiřina (203 Czech Republic, guarantor, belonging to the institution), Martina LÁNOVÁ (203 Czech Republic, belonging to the institution) and Jiří PACHERNÍK (203 Czech Republic, belonging to the institution)
Edition
Biomolecular concepts, 2012, 1868-5021
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30105 Physiology
Country of publisher
Germany
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
RIV identification code
RIV/00216224:14310/12:00063603
Organization unit
Faculty of Science
Keywords in English
ABC transporters; evolution; site mutations
Změněno: 13/5/2016 16:30, Mgr. Jiří Pacherník, Ph.D.
Abstract
V originále
Overexpression of ATP-binding cassette (ABC) transporters in cancer cells results in multidrug resistance (MDR) which leads to unsuccessful chemotherapy. The most important MDR-associated members of ABC superfamily are ABC B1/P-glycoprotein/MDR1, ABC C1/multidrug resistance associated protein 1 (MRP1), and ABC G2/BCRP. This study is not only focused on function, substrates, and localization of these popular proteins but also on other ABC C family members such as ABC C2–6/MRP2-6 and ABC C7/CFTR. Current research is mainly oriented on the cancer-promoting role of these proteins, but important lessons could also be learned from the physiological roles of these proteins or from polymorphisms affecting their function. Thorough knowledge of structure and detailed mechanism of efflux can aid in the discovery of new chemotherapy targets in the future. Although the best way on how to deal with MDR would be to prevent its development, we describe some new promising strategies on how to conquer both inherited and induced MDRs.
Links
MUNI/A/0975/2009, interní kód MU |
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