J 2010

Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte

OHLÍDALOVÁ, Dana, Michal PÁSEK, Jiří ŠIMURDA and Georges CHRISTÉ

Basic information

Original name

Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte

Name in Czech

Fyziologické důsledky iontově-koncentračních změn v transverzálně-axiálním tubulárním systému v modelu lidské srdeční komorové buňky

Authors

OHLÍDALOVÁ, Dana, Michal PÁSEK, Jiří ŠIMURDA and Georges CHRISTÉ

Edition

Analysis of Biomedical Signals and Images, Brno, Brno, VUTIUM Press, 2010, 1211-412X

Other information

Type of outcome

Article in a journal

Confidentiality degree

is not subject to a state or trade secret

Keywords in English

cardiac cell; transverse-axial tubular system; quantitative model

Tags

International impact, Reviewed
Changed: 9/5/2013 16:43, Mgr. Dana Hrabcová

Abstract

V originále

A mathematical model of human ventricular cell incorporating the transverse axial tubular system (TATS) was designed and used to explore the role of TATS in human ventricular cell electrophysiological activity. The model is based on the latest quantitative description of guinea pig ventricular cell electrophysiology and modified to respect the published data obtained from human cardiac preparations. Computer simulations suggest that significant transient depletions of Ca2+ ions and accumulation of K+ ions may occur in the human TATS. The preliminary analysis of the effects of tubular Ca2+depletions on the activity of the model cell indicates their role in limitation of intracellular Ca2+ overload at higher frequencies of stimulation.

Links

MSM0021622402, plan (intention)
Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases