HOLÁ, Veronika, Tereza PEROUTKOVÁ and Filip RŮŽIČKA. Virulence factors in Proteus bacteria from biofilm communities of catheter-associated urinary tract infections. FEMS Immunology and Medical Microbiology. WILEY-BLACKWELL, 2012, vol. 65, No 2, p. 343-349. ISSN 0928-8244. doi:10.1111/j.1574-695X.2012.00976.x.
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Basic information
Original name Virulence factors in Proteus bacteria from biofilm communities of catheter-associated urinary tract infections
Authors HOLÁ, Veronika (203 Czech Republic, guarantor, belonging to the institution), Tereza PEROUTKOVÁ (203 Czech Republic, belonging to the institution) and Filip RŮŽIČKA (203 Czech Republic, belonging to the institution).
Edition FEMS Immunology and Medical Microbiology, WILEY-BLACKWELL, 2012, 0928-8244.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.684
RIV identification code RIV/00216224:14110/12:00064950
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1111/j.1574-695X.2012.00976.x
UT WoS 000305279100022
Keywords in English biofilm; CAUTI; virulence factors; motility; catheter
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 10. 2. 2013 14:31.
Abstract
More than 40% of nosocomial infections are those of the urinary tract, most of these occurring in catheterized patients. Bacterial colonization of the urinary tract and catheters results not only in infection, but also various complications, such as blockage of catheters with crystalline deposits of bacterial origin, generation of gravels and pyelonephritis. The diversity of the biofilm microbial community increases with duration of catheter emplacement. One of the most important pathogens in this regard is Proteus mirabilis. The aims of this study were to identify and assess particular virulence factors present in catheter-associated urinary tract infection (CAUTI) isolates, their correlation and linkages: three types of motility (swarming, swimming and twitching), the ability to swarm over urinary catheters, biofilm production in two types of media, urease production and adherence of bacterial cells to various types of urinary tract catheters. We examined 102 CAUTI isolates and 50 isolates taken from stool samples of healthy people. Among the microorganisms isolated from urinary catheters, significant differences were found in biofilm-forming ability and the swarming motility. In comparison with the control group, the microorganisms isolated from urinary catheters showed a wider spectrum of virulence factors. The virulence factors (twitching motility, swimming motility, swarming over various types of catheters and biofilm formation) were also more intensively expressed.
Links
NS9678, research and development projectName: Biofilm - významný faktor virulence u infekcí močových katétrů; detekce a možnosti ovlivnění
Investor: Ministry of Health of the CR
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