Detailed Information on Publication Record
2012
Význam biomarkerů NGAL a cystatinu C u kardiovaskulárních onemocnění
HELÁNOVÁ, Kateřina, Jiří PAŘENICA, V. DLOUHÝ, Monika PÁVKOVÁ GOLDBERGOVÁ, Zdeňka ČERMÁKOVÁ et. al.Basic information
Original name
Význam biomarkerů NGAL a cystatinu C u kardiovaskulárních onemocnění
Name in Czech
Význam biomarkerů NGAL a cystatinu C u kardiovaskulárních onemocnění
Name (in English)
The importance of NGAL and cystatin C biomarkers on cardiovascular diseases
Authors
HELÁNOVÁ, Kateřina (203 Czech Republic, guarantor), Jiří PAŘENICA (203 Czech Republic, belonging to the institution), V. DLOUHÝ (203 Czech Republic), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic, belonging to the institution), Zdeňka ČERMÁKOVÁ (203 Czech Republic, belonging to the institution), Jana GOTTWALDOVÁ (203 Czech Republic, belonging to the institution) and Jindřich ŠPINAR (203 Czech Republic, belonging to the institution)
Edition
Vnitřní lékařství, 2012, 0042-773X
Other information
Language
Czech
Type of outcome
Článek v odborném periodiku
Field of Study
30201 Cardiac and Cardiovascular systems
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/12:00063696
Organization unit
Faculty of Medicine
Keywords (in Czech)
cystatin C - NGAL - biomarker
Keywords in English
cystatin C - NGAL - biomarker
Změněno: 18/2/2013 17:05, prof. RNDr. Monika Pávková Goldbergová, Ph.D.
V originále
Cystatin C is an inhibitor of lysosomal proteases and extracellular cysteine protease, it participates in the regulation of metabolism of extracellular proteins. It is fully glomerular filterable, completely absorbed and catabolised in proximal tubule cells. NGAL (neutrophil gelatinase-associated lipocalin) is an acute phase protein, participating in antibacterial immunity and his important feature is the formation of complex with metalloproteinase 9 (MMP-9), thereby increasing its activity and prevents its degradation. NGAL is freely filtered across the glomerular membrane and is reabsorbed by endocytosis in the proximal tubule. NGAL detected in urine is produced mainly in the distal nephron. The serum cystatin C and NGAL can diagnose acute renal impairment one or two days earlier in the comparison with the monitoring of renal function by serum creatinine. Moreover, compared with the information provided by creatinine or by estimated GFR, the elevated cystatin C gives, in patients with cardiovascular disease, information about worse prognosis. Increased level of NGAL was detected in patients with acute myocardial infarction, heart failure or stroke. There is a lack of data about the prognostic significance of NGAL in patients after myocardial infarction or heart failure, no data about their comparison or interaction with natriuretic peptides exists up today.
In English
Cystatin C is an inhibitor of lysosomal proteases and extracellular cysteine protease, it participates in the regulation of metabolism of extracellular proteins. It is fully glomerular filterable, completely absorbed and catabolised in proximal tubule cells. NGAL (neutrophil gelatinase-associated lipocalin) is an acute phase protein, participating in antibacterial immunity and his important feature is the formation of complex with metalloproteinase 9 (MMP-9), thereby increasing its activity and prevents its degradation. NGAL is freely filtered across the glomerular membrane and is reabsorbed by endocytosis in the proximal tubule. NGAL detected in urine is produced mainly in the distal nephron. The serum cystatin C and NGAL can diagnose acute renal impairment one or two days earlier in the comparison with the monitoring of renal function by serum creatinine. Moreover, compared with the information provided by creatinine or by estimated GFR, the elevated cystatin C gives, in patients with cardiovascular disease, information about worse prognosis. Increased level of NGAL was detected in patients with acute myocardial infarction, heart failure or stroke. There is a lack of data about the prognostic significance of NGAL in patients after myocardial infarction or heart failure, no data about their comparison or interaction with natriuretic peptides exists up today.
Links
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