J 2012

Prostatický specifický antigen, metalothionein a caveolin-1 jako markery vzniku a rozvoje karcinomu prostaty

SZTALMACHOVÁ, Markéta, Jaromír GUMULEC, Natalia Vladimirovna CERNEI, Marián HLAVNA, Ondřej ZÍTKA et. al.

Basic information

Original name

Prostatický specifický antigen, metalothionein a caveolin-1 jako markery vzniku a rozvoje karcinomu prostaty

Name (in English)

Prostate Specific Antigen, Metallothionein and Caveolin-1 as Markers of Formation and Development of Prostate Carcinom

Authors

SZTALMACHOVÁ, Markéta (203 Czech Republic, belonging to the institution), Jaromír GUMULEC (203 Czech Republic, belonging to the institution), Natalia Vladimirovna CERNEI (498 Republic of Moldova), Marián HLAVNA (703 Slovakia, belonging to the institution), Ondřej ZÍTKA (203 Czech Republic), Petr BABULA (203 Czech Republic), Vojtěch ADAM (203 Czech Republic), René KIZEK (203 Czech Republic) and Michal MASAŘÍK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Chemické listy, Praha, Česká společnost chemická, 2012, 0009-2770

Other information

Language

Czech

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 0.453

RIV identification code

RIV/00216224:14110/12:00063797

Organization unit

Faculty of Medicine

DOI

UT WoS

000311583300010

Keywords (in Czech)

karcinom prostaty;metalothionein;prostatický specifický antigen;caveolin-1

Keywords in English

prostate cancer;metallothionein;prostatic specific antigen;caveolin-1
Změněno: 22/4/2013 13:41, Ing. Mgr. Věra Pospíšilíková

Abstract

ORIG EN

V originále

Cílem naší práce bylo popsat rozdíly mezi „zdravou“ prostatickou tkání, nízce maligním primárním nádorem a agresivní formou onemocnění se schopností metastázo- vat. Pro naše experimenty byly vybrány geny metalo- thionein, caveolin-1 a PSA. U těchto genů byla stanovena exprese na RNA úrovni a také na úrovni proteinu u mode- lových buněčných linií.

In English

The current diagnostic limitations of prostate cancer have shown that the development of new approaches to early detection of aggressive forms of of the cancer is very important. A comprehensive approach to detection of potential tumour markers using different methods and their optimization is described. We focused on caveolin-1 and metallothionein and the obtained results were compared with prostate specific antigen as a golden standard of prostate cancer markers. All the mentioned markers were detected on both the mRNA and protein levels in three types of prostate cell lines. Metallothionein and caveolin-1 rank among the promising markers in prostate cancer diagnosis, especially. for distinguishing aggressive silent forms of the disease.