SZTALMACHOVÁ, Markéta, Jaromír GUMULEC, Natalia Vladimirovna CERNEI, Marián HLAVNA, Ondřej ZÍTKA, Petr BABULA, Vojtěch ADAM, René KIZEK and Michal MASAŘÍK. Prostatický specifický antigen, metalothionein a caveolin-1 jako markery vzniku a rozvoje karcinomu prostaty (Prostate Specific Antigen, Metallothionein and Caveolin-1 as Markers of Formation and Development of Prostate Carcinom). Chemické listy. Praha: Česká společnost chemická, 2012, vol. 106, No 11, p. 1075-1080. ISSN 0009-2770. Available from: https://dx.doi.org/10.1039/c2ib00157h.
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Basic information
Original name Prostatický specifický antigen, metalothionein a caveolin-1 jako markery vzniku a rozvoje karcinomu prostaty
Name (in English) Prostate Specific Antigen, Metallothionein and Caveolin-1 as Markers of Formation and Development of Prostate Carcinom
Authors SZTALMACHOVÁ, Markéta (203 Czech Republic, belonging to the institution), Jaromír GUMULEC (203 Czech Republic, belonging to the institution), Natalia Vladimirovna CERNEI (498 Republic of Moldova), Marián HLAVNA (703 Slovakia, belonging to the institution), Ondřej ZÍTKA (203 Czech Republic), Petr BABULA (203 Czech Republic), Vojtěch ADAM (203 Czech Republic), René KIZEK (203 Czech Republic) and Michal MASAŘÍK (203 Czech Republic, guarantor, belonging to the institution).
Edition Chemické listy, Praha, Česká společnost chemická, 2012, 0009-2770.
Other information
Original language Czech
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 0.453
RIV identification code RIV/00216224:14110/12:00063797
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1039/c2ib00157h
UT WoS 000311583300010
Keywords (in Czech) karcinom prostaty;metalothionein;prostatický specifický antigen;caveolin-1
Keywords in English prostate cancer;metallothionein;prostatic specific antigen;caveolin-1
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 22/4/2013 13:41.
Abstract
Cílem naší práce bylo popsat rozdíly mezi „zdravou“ prostatickou tkání, nízce maligním primárním nádorem a agresivní formou onemocnění se schopností metastázo- vat. Pro naše experimenty byly vybrány geny metalo- thionein, caveolin-1 a PSA. U těchto genů byla stanovena exprese na RNA úrovni a také na úrovni proteinu u mode- lových buněčných linií.
Abstract (in English)
The current diagnostic limitations of prostate cancer have shown that the development of new approaches to early detection of aggressive forms of of the cancer is very important. A comprehensive approach to detection of potential tumour markers using different methods and their optimization is described. We focused on caveolin-1 and metallothionein and the obtained results were compared with prostate specific antigen as a golden standard of prostate cancer markers. All the mentioned markers were detected on both the mRNA and protein levels in three types of prostate cell lines. Metallothionein and caveolin-1 rank among the promising markers in prostate cancer diagnosis, especially. for distinguishing aggressive silent forms of the disease.
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